{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:25:51Z","timestamp":1785432351562,"version":"3.56.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Hangzhou Medical and Health Science and Technology Project","award":["ZD20240007"],"award-info":[{"award-number":["ZD20240007"]}]},{"name":"Key Project of Zhejiang Provincial Natural Science Foundation","award":["LBZ24H190001"],"award-info":[{"award-number":["LBZ24H190001"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Nontuberculous mycobacteria (NTM) are opportunistic pathogens, and the global incidence of NTM diseases has been steadily increasing, posing significant public health challenges. This study retrospectively analyzed clinical data from 136 cases of NTM disease diagnosed at the Zhejiang Provincial Tuberculosis Diagnosis and Treatment Center between 2019 and 2022. It was observed that NTM diseases in this region predominantly affected middle-aged and elderly men, with chronic cough being the principal symptom (74.3%). Bronchiectasis (57.4%) and cavities (38.2%) were the main imaging characteristics. The results of species identification demonstrated that\n                      <jats:italic toggle=\"yes\">Mycobacterium intracellulare<\/jats:italic>\n                      (62.5%) was the dominant strain. Antimicrobial susceptibility testing revealed that\n                      <jats:italic toggle=\"yes\">Mycobacterium avium<\/jats:italic>\n                      complex exhibited relatively favorable sensitivity to clarithromycin, amikacin, ethambutol, rifapentine, rifampicin, and moxifloxacin, while the\n                      <jats:italic toggle=\"yes\">Mycobacterium chelonae\/Mycobacterium abscessus<\/jats:italic>\n                      complex showed sensitivity only to amikacin (66.7%). In total, 66.2% of patients received anti-NTM therapy. Patients completing \u22656 months of treatment achieved significantly higher efficacy than those with &lt;6 months (81.82% vs 57.14%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). The study highlights that NTM diseases in this region are predominantly caused by\n                      <jats:italic toggle=\"yes\">M. intracellulare<\/jats:italic>\n                      , with characteristic clinical\/imaging features aiding diagnosis. Treatment regimens guided by susceptibility testing and maintained for \u22656 months significantly improve outcomes, emphasizing the importance of species identification and standardized therapeutic duration in NTM management. These findings provide evidence-based insights for optimizing regional NTM diagnosis and treatment strategies.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>Nontuberculous mycobacteria (NTM) infections are rising globally, but their characteristics vary by region, complicating diagnosis and treatment. This study addresses a critical gap by analyzing 136 cases from Eastern China, providing the first detailed insights into local NTM disease patterns. By linking pathogen types, drug resistance, and treatment duration to outcomes, this work equips doctors in Eastern China to diagnose faster, choose effective therapies, and improve patient survival. These findings also urge policymakers to prioritize localized data collection and standardized protocols for NTM management globally.<\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.01374-25","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T14:01:07Z","timestamp":1765288867000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics, antimicrobial susceptibility patterns, and treatment outcomes of nontuberculous mycobacterial diseases in eastern China: a retrospective cohort study (2019\u20132022)"],"prefix":"10.1128","volume":"14","author":[{"given":"Huijie","family":"Wang","sequence":"first","affiliation":[{"name":"Tuberculosis Department, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Hua","sequence":"additional","affiliation":[{"name":"Tuberculosis Department, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Tuberculosis Department, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8848-0330","authenticated-orcid":false,"given":"Qiang","family":"Zhan","sequence":"additional","affiliation":[{"name":"Tuberculosis Department, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9017-7835","authenticated-orcid":true,"given":"Huaqiong","family":"Huang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/059cjpv64","id-type":"ROR","asserted-by":"publisher"}],"name":"Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1125"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65933-x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00027"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.05.001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.10.013"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.2096-8493.2021.02.004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-021-00844-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2014.10.002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid170310060"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201804-236OC"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2406.172095"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.14.60"},{"key":"e_1_3_2_14_2","series-title":"CLSI Document M24S","volume-title":"Performance standards for susceptibility testing of mycobacteria, Nocardia spp., and other aerobic actinomycetes","author":"Parrish NM","year":"2023","unstructured":"Parrish NM, Wengenack NL, Barker A. 2023. 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