{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:35:43Z","timestamp":1791588943224,"version":"4.3.4"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"crossref","award":["24-24-00087"],"award-info":[{"award-number":["24-24-00087"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004285","name":"Saint Petersburg State University","doi-asserted-by":"crossref","award":["project 124032000041-1"],"award-info":[{"award-number":["project 124032000041-1"]}],"id":[{"id":"10.13039\/501100004285","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004285","name":"Saint Petersburg State University","doi-asserted-by":"crossref","award":["PURE ID 95444211"],"award-info":[{"award-number":["PURE ID 95444211"]}],"id":[{"id":"10.13039\/501100004285","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"crossref","award":["projects FSMG-2023-018 (agreement # 075-03-2023-106\/12) and (agreement # FGFG-2024-002)"],"award-info":[{"award-number":["projects FSMG-2023-018 (agreement # 075-03-2023-106\/12) and (agreement # FGFG-2024-002)"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2025,1,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Many studies have reported gut microbiome alterations in psoriasis patients, suggesting dysbiosis. While evidence for dysbiosis and its link to pathogenesis remains inconclusive, murine models of psoriasis suggest that gut microbiome alterations develop in response to psoriasis-like inflammation. Hence, the dominant narrative about gut microbiome alterations\u2019 impact on disease should be evaluated critically with more data and a well-powered approach. In this case-control study, we used deep sequencing of fecal samples from 53 psoriasis patients and 47 healthy donors to reconstruct the strain\/species-level content of the gut microbiome. Unlike previous studies, we first identified matched pairs for each patient with healthy donors to adjust for microbiome variability and increase power. We found no evidence for depleted gut community diversity and apparent divergence in structure between patients and healthy individuals. However, our matched-pair approach identified a subtle but systematic increase in select bacteria among patients, e.g.,\n              <jats:italic>Megasphaera elsdenii<\/jats:italic>\n              and\n              <jats:italic>Eubacterium CAG 180<\/jats:italic>\n              . We next showed that these enriched species were correlated with elevated biomarkers of intestinal and systemic inflammation and liver function. Functionally, one of the top species,\n              <jats:italic>Megasphaera elsdenii<\/jats:italic>\n              , is a potent lactate utilizer in the context of intestinal lactic acidosis and inflammation. While our findings hardly support overt dysbiosis in the large intestine, the observed microbial changes correlate with moderately elevated calprotectin, albeit at levels not enough to diagnose ongoing inflammation. Hence, the sources of elevated inflammatory markers in patients\u2019 intestines remain unclear and warrant further investigation to clarify their cause-and-effect relationship with the disease.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>With sufficient taxonomic resolution and sample size, this study critically evaluates new and published data on the gut microbiome in psoriasis patients. It shows that observed taxonomic changes in patients are modest and do not meet strict criteria for gut dysbiosis, at least in the large intestine. Instead, observed taxonomic changes in psoriasis patients can be explained by the microbial response to possible low-grade inflammation with unknown localization in the intestine and unclear impact on the host. The authors point out that published endoscopic data point to the small intestine as the site of gut inflammation. Therefore, further research focused on the small intestine would be informative to clarify the hypothetical gut-psoriasis link.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/spectrum.01382-24","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T14:05:24Z","timestamp":1733839524000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Gut dysbiosis narrative in psoriasis: matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6035-8763","authenticated-orcid":true,"given":"Bayazit","family":"Yunusbayev","sequence":"first","affiliation":[{"name":"Institute of Translational Biomedicine, Saint-Petersburg State University","place":["Saint-Petersburg, Russia"]},{"name":"Department of Genetics and Biotechnology, Saint-Petersburg State University","place":["Saint-Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bogdanova","sequence":"additional","affiliation":[{"name":"SCAMT institute, ITMO University","place":["Saint Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezhda","family":"Nadyrchenko","sequence":"additional","affiliation":[{"name":"Republican Dermatovenerologic Dispensary","place":["Ufa, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavrentii","family":"Danilov","sequence":"additional","affiliation":[{"name":"Department of Genetics and Biotechnology, Saint-Petersburg State University","place":["Saint-Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Bogdanov","sequence":"additional","affiliation":[{"name":"Multiomics Laboratory, Moscow Institute of Physics and Technology","place":["Moscow, Russia"]},{"name":"Medical Genetics Laboratory, Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigory","family":"Sergeev","sequence":"additional","affiliation":[{"name":"SCAMT institute, ITMO University","place":["Saint Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radick","family":"Altinbaev","sequence":"additional","affiliation":[{"name":"Institute of Higher Nervous Activity and Neurophysiology of RAS","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanil","family":"Bilalov","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Bashkir State Medical University","place":["Ufa, Russia"]},{"name":"Republic Medical Genetic Centre","place":["Ufa, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milyausha","family":"Yunusbaeva","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, Saint-Petersburg State University","place":["Saint-Petersburg, Russia"]},{"name":"Department of Genetics and Biotechnology, Saint-Petersburg State University","place":["Saint-Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2018.7"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2023.103114"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042718-041841"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042915-103905"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17931"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.7"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12308"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01492-17"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01154-23"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1331521"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","unstructured":"Rahman G McDonald D Gonzalez A V\u00e1zquez-Baeza Y Jiang L Casals-Pascual C Peddada S Hakim D Dilmore AH Nowinski B Knight R. 2022. Scalable power analysis and effect size exploration of microbiome community differences with Evident. Bioinformatics. doi:10.1101\/2022.05.19.492684","DOI":"10.1101\/2022.05.19.492684"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.15931.2"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.2.573"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx754"},{"key":"e_1_3_5_17_2","volume-title":"Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3","author":"Beghini F","year":"2020","unstructured":"Beghini F, McIver LJ, Blanco-M\u00edguez A, Dubois L, Asnicar F, Maharjan S, Mailyan A, Thomas AM, Manghi P, Valles-Colomer M, Weingart G, Zhang Y, Zolfo M, Huttenhower C, Franzosa EA, Segata N. 2020. Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3. Cold Spring Harbor Laboratory."},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn5166"},{"key":"e_1_3_5_19_2","volume-title":"Tools for microbiome analysis in R","author":"Leo Lahti SS","year":"2017","unstructured":"Leo Lahti SS. 2017. Tools for microbiome analysis in R."},{"key":"e_1_3_5_20_2","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2022","unstructured":"R Core Team. 2022. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria."},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2015.02.019"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/pan\/mpl013"},{"key":"e_1_3_5_23_2","volume-title":"microbiotaPair: an R package for simplified microbiome analysis workflows on intervention study","author":"Ren H","year":"2020","unstructured":"Ren H. 2020. microbiotaPair: an R package for simplified microbiome analysis workflows on intervention study."},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009442"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005752"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11234"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy167"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02467-22"},{"key":"e_1_3_5_29_2","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm1511","article-title":"Intestinal species contribute to autoantibody production and bone erosion in rheumatoid arthritis","volume":"8","author":"He J","year":"2022","unstructured":"He J, Chu Y, Li J, Meng Q, Liu Y, Jin J, Wang Y, Wang J, Huang B, Shi L, Shi X, Tian J, Zhufeng Y, Feng R, Xiao W, Gan Y, Guo J, Shao C, Su Y, Hu F, Sun X, Yu J, Kang Y, Li Z. 2022. Intestinal species contribute to autoantibody production and bone erosion in rheumatoid arthritis. Sci Adv 8:eabm1511.","journal-title":"Sci Adv"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2022.100115"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22125-y"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19940-1"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324855"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0675-0"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14933"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01389-7"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1017\/gmb.2022.3"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skaa248"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079353"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2020.103085"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.5713\/ab.22.0258"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.09.010"},{"key":"e_1_3_5_43_2","first-page":"11265","article-title":"Toll-like receptor 7 agonist-induced dermatitis causes severe dextran sulfate sodium colitis by altering the gut microbiome and immune cells","volume":"11","author":"Shinno-Hashimoto H","year":"2021","unstructured":"Shinno-Hashimoto H, Hashimoto Y, Wei Y, Chang L, Fujita Y, Ishima T, Matsue H, Hashimoto K. 2021. Toll-like receptor 7 agonist-induced dermatitis causes severe dextran sulfate sodium colitis by altering the gut microbiome and immune cells. Sci Rep 11:11265.","journal-title":"Sci Rep"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2016.06.003"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1448626"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2019.07.006"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05989-7"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00777-z"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-024-01225-y"},{"key":"e_1_3_5_50_2","unstructured":"Shagova YV. 2009. Clinical and prognostic value of functional and structural alterations of the intestine in psoriasis (\u041a\u043b\u0438\u043d\u0438\u043a\u043e-\u043f\u0440\u043e\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0445 \u0438 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u043d\u044b\u0445 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0439 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0430 \u043f\u0440\u0438 \u043f\u0441\u043e\u0440\u0438\u0430\u0437\u0435). Ph.D. in Medicine (Candidate of Sciences in Medicine). Saratov State Medical University."},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/aisy.201900053"}],"container-title":["Microbiology Spectrum"],"original-title":[],"contributor":[{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]}],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01382-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01382-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T14:05:45Z","timestamp":1736258745000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.01382-24"}},"subtitle":[],"editor":[{"given":"Jennifer M.","family":"Auchtung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,7]]}},"alternative-id":["10.1128\/spectrum.01382-24"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.01382-24","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]},"assertion":[{"value":"2024-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01382-24"}}