{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:15:11Z","timestamp":1788225311154,"version":"build-2803163510"},"reference-count":92,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Toxoplasma gondii<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      ) relies on host cells for energy and nutrition. Our previous studies showed that\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      regulates host cell apoptosis via the mitochondrial pathway, highlighting the essential role of mitochondria in its parasitism. In this study,\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      infection was found to significantly affect mitochondrial morphology and dynamic homeostasis in porcine kidney-15 (PK-15) cells, characterized by aggregated, swollen, fragmented, and oval-shaped mitochondria with disappearing cristae, accompanied by increased fusion and decreased fission. Additionally, the energy metabolic reprogramming of PK-15 cells exposed to\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      was affirmed from the perspectives of glucose consumption; changes in NAD\n                      <jats:sup>+<\/jats:sup>\n                      \/NADH, lactate, pyruvate, and ATP production; and expressions of proteins related to glycolysis and oxidative phosphorylation (OXPHOS).\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      -induced mitochondrial damage impaired the OXPHOS process; however, the glycolysis level was significantly increased. Mechanistically, we demonstrated that activation of phosphatidylinositol 3-kinase (PI3K)\/protein kinase B (Akt)\/mammalian target of rapamycin (mTOR) signaling pathway played a critical role in energy metabolic reprogramming and mitochondrial damage induced by\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      , and this effect could be attenuated by LY294002 (a PI3K inhibitor), which significantly reduced intracellular proliferation of\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      through inhibiting PI3K\/Akt\/mTOR signaling pathway. These findings highlight the PI3K\/Akt\/mTOR pathway as a key mediator of\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      -induced cellular metabolic reprogramming and mitochondrial dysfunction; however, its potential as a therapeutic target remains to be validated\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      .\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        <jats:italic toggle=\"yes\">Toxoplasma gondii<\/jats:italic>\n                        , a globally distributed obligate intracellular protozoan parasite, poses severe health risks to immunocompromised individuals and pregnant women, causing miscarriage and fetal abnormalities. Current therapies suffer from high toxicity and limited targets, with unclear mechanisms underlying host-parasite interactions. This study reveals a novel parasitic strategy:\n                        <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                        hijacks host mitochondrial dynamics and energy metabolism. Infection disrupts mitochondrial morphology and suppresses oxidative phosphorylation while activating the PI3K\/Akt\/mammalian target of rapamycin (mTOR) pathway to drive metabolic reprogramming, enhancing glycolysis to meet energy demands. Critically, inhibiting PI3K\/Akt\/mTOR with LY294002 reduces intracellular parasite proliferation, validating this pathway as a therapeutic target. Conventional antiparasitic drugs targeting the parasite directly face resistance challenges. By focusing on host metabolic regulation via PI3K\/Akt\/mTOR, this work advances understanding of parasitism and proposes host-directed therapies to disrupt parasite proliferation by modulating the metabolic microenvironment, highlighting its therapeutic potential against toxoplasmosis.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.01385-25","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:53:56Z","timestamp":1766415236000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["PI3K\/Akt\/mTOR signaling pathway mediates energy metabolic reprogramming and regulates mitochondrial homeostasis in host cells exposed to\n                    <i>Toxoplasma 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