{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:05:19Z","timestamp":1783699519627,"version":"3.55.0"},"reference-count":56,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG045044"],"award-info":[{"award-number":["R01AG045044"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI123654"],"award-info":[{"award-number":["R01AI123654"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2021,12,22]]},"abstract":"<jats:p>Despite the global success of vaccination with pneumococcal conjugate vaccines, serotype 3 (ST3) pneumococcus remains a leading cause of morbidity and mortality. In comparison to other vaccine-included serotypes, the ST3 pneumococcal capsular polysaccharide (PPS3) induces a weaker opsonophagocytic response, which is considered a correlate of vaccine efficacy.<\/jats:p>","DOI":"10.1128\/spectrum.01446-21","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T10:33:47Z","timestamp":1636540427000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Isolation and Characterization of Human Monoclonal Antibodies to Pneumococcal Capsular Polysaccharide 3"],"prefix":"10.1128","volume":"9","author":[{"given":"Rachelle","family":"Babb","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine &amp; Montefiore Medical Center, Bronx, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Doyle","sequence":"additional","affiliation":[{"name":"WCG IBC Services, Puyallup, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liise-anne","family":"Pirofski","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine &amp; Montefiore Medical Center, Bronx, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2019.10.056"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70822-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.02.096"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226353"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes10110845"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.13.2.165-169.2006"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.09.029"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05313-11"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.8.4653-4667.2005"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00591-15"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01075-08"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.06081-11"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02260-15"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.4.1820-1826.2000"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.9.4977-4986.2002"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00300-18"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.22.4.457"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.22.4.484"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00176-11"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.09.009"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00800-21"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.55"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.71"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.4.4.415-422.1997"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-013-0601-1"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00410-09"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.196-208.2004"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.3.1172-1179.1999"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.11.7465-7476.2005"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.6.3505-3514.2004"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402890"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.08.278"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.4236\/oji.2012.23012"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf5347"},{"key":"e_1_3_3_36_2","first-page":"847","article-title":"Agglutination and phagocytosis of pneumococci by immunoglobulin G antibodies of restricted heterogeneity","volume":"101","author":"Reed WP","year":"1983","unstructured":"Reed WP, Stromquist DL, Williams RC, Jr. 1983. Agglutination and phagocytosis of pneumococci by immunoglobulin G antibodies of restricted heterogeneity. J Lab Clin Med 101:847\u2013856.","journal-title":"J Lab Clin Med"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540310015854"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-1018-x"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01829-14"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.11.2931-2939.2002"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00477-08"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1729-4"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.8.4389-4398.2002"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl560"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.2.853-864.2001"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.1.405"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.04.026"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb5642"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830230120"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.9.3446-3450.1996"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2007.09.017"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.3"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2016.09.001"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01371-06"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00881-09"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170884"},{"key":"e_1_3_3_57_2","first-page":"89","volume-title":"A\u2013Z of Quantitative PCR.","author":"Pfaffl MW","year":"2004","unstructured":"Pfaffl MW. 2004. Quantification strategies in real-time PCR, p 89\u2013113. In A\u2013Z of Quantitative PCR. Center of Life and Food Science Weihenstephan, Freising, Germany."}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/Spectrum.01446-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/Spectrum.01446-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T03:56:11Z","timestamp":1646711771000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/Spectrum.01446-21"}},"subtitle":[],"editor":[{"given":"Joanna B.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,12,22]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,12,22]]}},"alternative-id":["10.1128\/Spectrum.01446-21"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.01446-21","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.08.02.454853","asserted-by":"object"}]},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,22]]},"assertion":[{"value":"2021-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01446-21"}}