{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:33:24Z","timestamp":1787729604884,"version":"build-2784847793"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82574172, 82003516"],"award-info":[{"award-number":["82574172, 82003516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      As an alternative to the tuberculin skin test (TST) or QuantiFERON-TB Gold In-Tube (QFT-GIT), ESAT6-CFP10 (EC) skin test is an emerging screening method; however, its value in the diagnosis of latent tuberculosis infection (LTBI) in detainees is still unclear in China. Newly admitted detainees meeting inclusion criteria were enrolled, with demographic\/clinical data collected via structured questionnaires. TST, EC skin test, and QFT-GIT screenings were performed, documenting the diameter of skin indurations and\/or redness at injection sites and blistering reactions at injection sites. In total, 1,038 detainees were enrolled in this study from October 2022 to October 2023 with 236 LTBI (22.7%). The positive rate of TST, EC skin test, and QFT-GIT was 18.1%, 10.6% and 11.9%. The area under the curve for EC was 0.820, indicating a strong concordance with QFT-GIT (\u03ba = 0.673). Compared with QFT-GIT, the sensitivity of EC was 66.9%, and the specificity was 97.0%. The mean induration diameter or redness of EC was significantly larger than that of TST (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). In the regression model, no history of alcohol consumption (aOR = 0.433, 95% confidence interval [CI]: 0.200, 0.938), no history of surgical trauma (aOR = 0.731, 95% CI: 0.539, 0.991), and no drug use (aOR = 0.473, 95% CI: 0.233, 0.961) was identified as a protective factor for LTBI. The EC demonstrated both high specificity and sensitivity comparable to the QFT-GIT. When screening for LTBI among jail detainees in this setting, particular attention should be given to individuals with a history of alcohol consumption, surgical trauma, and drug use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>Jail detainees represent a vulnerable population with an elevated risk of tuberculosis. The EC skin test demonstrates promising potential as an alternative to traditional diagnostic methods, such as the TST and QFT-GIT assay, for LTBI screening. Targeted screening strategies can facilitate the early detection, diagnosis, and management of LTBI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.01500-25","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T13:00:37Z","timestamp":1758114037000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic accuracy of the ESAT6-CFP10 skin test for latent tuberculosis infection among jail detainees"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2883-1112","authenticated-orcid":false,"given":"Xinru","family":"Fei","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02ey6qs66","id-type":"ROR","asserted-by":"publisher"}],"name":"Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province","place":["Nanjing City, 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