{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:54:20Z","timestamp":1791467660104,"version":"4.3.4"},"reference-count":33,"publisher":"American Society for Microbiology","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      spp. remain an important cause of bacterial gastrointestinal infection, but local data from maternal and child healthcare hospitals remain limited. This retrospective study analyzed\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      spp. isolated from fecal cultures of inpatients at Longgang District Maternity and Child Healthcare Hospital of Shenzhen City from 2021 to 2025. Fecal specimens were processed using routine selective culture procedures; isolates were identified with the VITEK 2 Compact system, with VITEK MS confirmation when required, and antimicrobial susceptibility was interpreted according to Clinical and Laboratory Standards Institute (CLSI) M100, 35th edition. Annual positivity and non-duplicate isolation rates were compared using Pearson \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests. A total of 106 non-duplicate isolates were recovered, including 98 from pediatric inpatients. Annual positivity and non-duplicate isolation rates differed significantly across the 5-year study period (both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and were highest in 2025. Among pediatric cases, children aged 1\u20133 years accounted for 79.6%, with the 12 to &lt;24-month group accounting for 52.0%. Resistance was high to ampicillin (76.7%), ampicillin\/sulbactam (63.3%), trimethoprim-sulfamethoxazole (46.6%), and ceftriaxone (36.9%). Resistance to ciprofloxacin and levofloxacin was 12.5% and 14.8%, respectively, although intermediate rates were high. Most isolates remained susceptible to piperacillin\/tazobactam and carbapenems. These findings show a concentration of laboratory-detected\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      among children aged 1\u20133 years, particularly those aged 12 to &lt;24 months, and substantial resistance to several commonly used agents, supporting continued local surveillance and susceptibility-guided antimicrobial use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      spp. remain an important bacterial cause of gastrointestinal infection in children, but local data from maternal and child healthcare hospitals are limited. This 5-year retrospective study describes the detection characteristics and antimicrobial resistance profiles of\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      spp. isolated from fecal cultures of inpatients in a maternal and child healthcare hospital in Shenzhen, China. The findings show that\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      isolates were mainly recovered from young pediatric patients and exhibited high resistance to several commonly used antimicrobial agents, including ampicillin, ampicillin\/sulbactam, trimethoprim-sulfamethoxazole, and ceftriaxone, while reduced susceptibility to fluoroquinolones was also observed. These results provide institution-specific evidence for empirical treatment decisions, antimicrobial stewardship, and continued surveillance of enteric bacterial pathogens in pediatric and maternal-child healthcare settings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.01536-26","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:00:56Z","timestamp":1791464456000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Detection characteristics and antimicrobial resistance profiles of\n                    <i>Salmonella<\/i>\n                    spp. isolated from fecal cultures of inpatients at a maternal and child healthcare hospital in Shenzhen: a 5-year retrospective study"],"prefix":"10.1128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6939-0057","authenticated-orcid":true,"given":"Tongyan","family":"Ding","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02gxych78","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Laboratory, Key Laboratory of Bacterial Antimicrobial Resistance and Prevention, Medical Research Institute of Maternal and Child, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College)","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxiang","family":"Lin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02gxych78","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Laboratory, Key Laboratory of Bacterial Antimicrobial Resistance and Prevention, Medical Research Institute of Maternal and Child, Longgang 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