{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:51:41Z","timestamp":1790725901474,"version":"4.1.0"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172907"],"award-info":[{"award-number":["32172907"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32002331"],"award-info":[{"award-number":["32002331"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20190893"],"award-info":[{"award-number":["BK20190893"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012431","name":"Jiangsu Agricultural Science and Technology Independent Innovation Fund","doi-asserted-by":"publisher","award":["CX(20)3091"],"award-info":[{"award-number":["CX(20)3091"]}],"id":[{"id":"10.13039\/501100012431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012431","name":"Jiangsu Agricultural Science and Technology Independent Innovation Fund","doi-asserted-by":"publisher","award":["CX(21)2010"],"award-info":[{"award-number":["CX(21)2010"]}],"id":[{"id":"10.13039\/501100012431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["2019"],"award-info":[{"award-number":["2019"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFD1801000"],"award-info":[{"award-number":["2021YFD1801000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2022,2,23]]},"abstract":"<jats:p>\n            Recently, high-level tigecycline resistance mediated by\n            <jats:italic>tet<\/jats:italic>\n            (X4) and its variants represents a serious challenge for global public health. Antibiotic adjuvant strategy that enhances the activity of the existing antibiotics by using nonantibiotic drugs offers a distinct approach to combat the antibiotic resistance crisis. In this study, we found that bismuth drugs involve bismuth nitrate, a compound previously approved for treatment of stomach-associated diseases, remarkably potentiates tigecycline activity against\n            <jats:italic>tet<\/jats:italic>\n            (X)-positive bacteria.\n          <\/jats:p>","DOI":"10.1128\/spectrum.01578-21","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T15:32:35Z","timestamp":1644420755000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Bismuth Drugs Reverse Tet(X)-Conferred Tigecycline Resistance in Gram-Negative Bacteria"],"prefix":"10.1128","volume":"10","author":[{"given":"Tian","family":"Deng","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwen","family":"Tong","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingru","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6486-9600","authenticated-orcid":true,"given":"Zhiqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-6471","authenticated-orcid":true,"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China"},{"name":"Institute of Comparative Medicine, Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(09)70005-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.07.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00424-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0445-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0496-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2019.1599813"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.06.009"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.56205"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10070769"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006635"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/d0sc04082g"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000292"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02280-17"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006276"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18939-y"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.11.s1.13.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666171003113540"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.01.006"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190915258"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02828-6"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-0877-5"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00439"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.609"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph14090907"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.00416-21"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1039\/d0cs00031k"},{"key":"e_1_3_3_28_2","first-page":"878","article-title":"Organobismuth chemistry in the past decade","volume":"20","author":"Zhang X","year":"2008","unstructured":"Zhang X, Yin S, Wu S. 2008. Organobismuth chemistry in the past decade. Prog Chem 20:878.","journal-title":"Prog Chem"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1421002112"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi010579t"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.41.29094"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(02)00649-9"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1039\/c7sc00766c"},{"key":"e_1_3_3_34_2","volume-title":"Performance standards for antimicrobial susceptibility testing.","author":"Clinical and Laboratory Standards Institute.","year":"2018","unstructured":"Clinical and Laboratory Standards Institute. 2018. Performance standards for antimicrobial susceptibility testing. CLSI, Wayne, PA."},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02854-z"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2021.05.003"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab592"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01578-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01578-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T08:55:53Z","timestamp":1646729753000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.01578-21"}},"subtitle":[],"editor":[{"given":"Tomefa E.","family":"Asempa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,23]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2,23]]}},"alternative-id":["10.1128\/spectrum.01578-21"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.01578-21","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,23]]},"assertion":[{"value":"2021-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01578-21"}}