{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:14:57Z","timestamp":1753881297326,"version":"3.41.2"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/national","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI150343"],"award-info":[{"award-number":["AI150343"]}],"id":[{"id":"10.13039\/national","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/national","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI141495"],"award-info":[{"award-number":["AI141495"]}],"id":[{"id":"10.13039\/national","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2021,12,22]]},"abstract":"<jats:p>Our previous mutagenesis study revealed that serine at position 534 of HIV-1 Env is critical for viral infectivity. We found that HIV-1 Env containing serine to proline mutation at position 534 (S534P) are incapable of supporting virus-cell and cell-cell fusion.<\/jats:p>","DOI":"10.1128\/spectrum.01653-21","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T18:37:09Z","timestamp":1642617429000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Reverted HIV-1 Mutants in CD4\n            <sup>+<\/sup>\n            T-Cells Reveal Critical Residues in the Polar Region of Viral Envelope Glycoprotein"],"prefix":"10.1128","volume":"9","author":[{"given":"Wuxun","family":"Lu","sequence":"first","affiliation":[{"name":"Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai-Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacia","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-2487","authenticated-orcid":true,"given":"Li","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.H117.791731"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.04.042"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2013.09.004"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00020-07"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi991887i"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603135200"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M703485200"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000880"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.299826"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02128-18"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01970-06"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.18.8358-8367.2000"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2012.229"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41434-020-00193-y"},{"key":"e_1_3_3_16_2","volume-title":"Human retroviruses and AIDS.","author":"Korber B","year":"1998","unstructured":"Korber B, Kuiken C, Pillai S, Sodroski J, et al. 1998. Numbering positions in HIV relative to HXB2CG. In Korber B, Foley B, (ed), Human retroviruses and AIDS. https:\/\/www.hiv.lanl.gov\/content\/sequence\/HIV\/REVIEWS\/HXB2.html. Los Alamos National Laboratory, Los Alamos, NM."}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01653-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01653-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T09:04:38Z","timestamp":1646730278000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.01653-21"}},"subtitle":[],"editor":[{"given":"Yongjun","family":"Sui","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,12,22]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,12,22]]}},"alternative-id":["10.1128\/spectrum.01653-21"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.01653-21","relation":{},"ISSN":["2165-0497"],"issn-type":[{"type":"electronic","value":"2165-0497"}],"subject":[],"published":{"date-parts":[[2021,12,22]]},"assertion":[{"value":"2021-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01653-21"}}