{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:19:08Z","timestamp":1792441148326,"version":"4.5.0"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Among 452 adult patients with Gram-negative bacteremia from a urinary tract infection source who received oral step-down therapy with highly bioavailable oral beta-lactam, we observed no difference in 60-day recurrence in patients treated with higher consensus-recommended dosing compared to lower, standard dosing (odds ratio = 0.76 [95% confidence interval = 0.43\u20131.32]), although the directionality of the effect was favorable. The study was limited by inadequate sample size and confounding. Randomized or large observational comparative effectiveness studies are needed.<\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>Definitive treatment of Gram-negative bacteremia with oral antibiotic agents is not one size fits all. Use of oral fluoroquinolones and sulfamethoxazole\/trimethoprim is evidence-based but carries risk for adverse events. Data supporting the use of oral beta-lactams are mixed, likely in part due to variable agent selection and dosing. This analysis shows that higher, consensus-recommended dosing of highly bioavailable beta-lactam antibiotics was not significantly different from patients treated with lower dosing on 60-day recurrence. Our study was limited by the number of patients with discrete MICs and overinfluence of complicated urinary tract infection on outcomes.<\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.01704-25","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T14:22:54Z","timestamp":1767190974000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Effect of oral beta-lactam dosing on outcomes of bacteremic Gram-negative urinary tract infections: a real-world analysis"],"prefix":"10.1128","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1552-2592","authenticated-orcid":true,"given":"Stephanie S.","family":"May","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mvr1r74","id-type":"ROR","asserted-by":"publisher"}],"name":"Infectious Diseases Telehealth Service, Intermountain Health","place":["Murray, USA"]},{"id":[{"id":"https:\/\/ror.org\/009c06z12","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacy, Intermountain Medical Center","place":["Murray, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7662-7609","authenticated-orcid":true,"given":"John J.","family":"Veillette","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mvr1r74","id-type":"ROR","asserted-by":"publisher"}],"name":"Infectious Diseases Telehealth Service, Intermountain Health","place":["Murray, USA"]},{"id":[{"id":"https:\/\/ror.org\/009c06z12","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacy, Intermountain Medical Center","place":["Murray, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison M.","family":"Butler","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mvr1r74","id-type":"ROR","asserted-by":"publisher"}],"name":"Statistical Data Center, Intermountain Health","place":["Murray, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Olson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/053hkmn05","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacy, Primary Children\u2019s Hospital","place":["Salt Lake City, USA"]},{"id":[{"id":"https:\/\/ror.org\/03r0ha626","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Pediatrics, University of Utah","place":["Salt Lake City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7802-8360","authenticated-orcid":false,"given":"Sameer","family":"Alzaidi","sequence":"additional","affiliation":[{"name":"King Abdul Aziz Specialist Hospital","place":["Taif, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1799-3315","authenticated-orcid":true,"given":"Brandon J.","family":"Webb","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009c06z12","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Clinical Epidemiology and Infectious Diseases, Intermountain Medical Center","place":["Murray, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab434"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq257"},{"key":"e_1_3_2_4_2","unstructured":"Infectious Diseases Society of America guideline on management and treatment of complicated urinary tract infections. 2025. 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