{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:20:07Z","timestamp":1792383607719,"version":"4.4.0"},"reference-count":58,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"MOST | National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["81790631"],"award-info":[{"award-number":["81790631"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Project of Jinan Microecological Biomedicine Shandong Laboratory","award":["JNL-2022001A"],"award-info":[{"award-number":["JNL-2022001A"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2022,10,26]]},"abstract":"<jats:p>Our study provides the first direct clues to the protective role of gasdermin D (GSDMD) in autoimmune hepatitis (AIH). We demonstrated that<jats:italic>Gsdmd<\/jats:italic>knockout exacerbated concanavalin A (ConA)-induced AIH in mice.<\/jats:p>","DOI":"10.1128\/spectrum.01717-22","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T13:03:31Z","timestamp":1660655011000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Multi-Omics Analysis Reveals the Protection of Gasdermin D in Concanavalin A-Induced Autoimmune Hepatitis"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3583-908X","authenticated-orcid":false,"given":"Kaicen","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenrui","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwan","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafeng","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4114-9402","authenticated-orcid":true,"given":"Longxian","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoxiang","family":"Zhuge","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjie","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanjuan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Jinan Microecological Biomedicine Shandong Laboratory, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2070"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.07.016"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.04.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12534"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18629"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15541"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.040"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15561"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1719-6"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30328-9"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1722759"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.18"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115836"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0023677215572841"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249682"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010111"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.19320"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep36365"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep07259"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01804"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00758"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3284-2"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.624360"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26321"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1521-8"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2001.02385.x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abk2092"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8690213"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.5.1529"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.11.002"},{"key":"e_1_3_3_33_2","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.4049\/jimmunol.159.3.1418","article-title":"Suppression of concanavalin A-induced hepatitis in IFN-gamma(\u2212\/\u2212) mice, but not in TNF-alpha(\u2212\/\u2212) mice: role for IFN-gamma in activating apoptosis of hepatocytes","volume":"159","author":"Tagawa Y","year":"1997","unstructured":"Tagawa Y, Sekikawa K, Iwakura Y. 1997. Suppression of concanavalin A-induced hepatitis in IFN-gamma(\u2212\/\u2212) mice, but not in TNF-alpha(\u2212\/\u2212) mice: role for IFN-gamma in activating apoptosis of hepatocytes. J Immunol 159:1418\u20131428.","journal-title":"J Immunol"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.004"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1946369"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1373"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3430"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1734423"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0070-2"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.11.001"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2019.1595708"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1966278"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9619"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111000"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.595382"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2634-9"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11351"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.750841"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz6717"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.9.2515S"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12970-014-0061-8"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110520"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111564"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24193"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr050364w"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1039\/c6mb00092d"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2437-9"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.11.009"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i44.6527"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01717-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01717-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:04:49Z","timestamp":1676419489000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.01717-22"}},"subtitle":[],"editor":[{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10,26]]}},"alternative-id":["10.1128\/spectrum.01717-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.01717-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]},"assertion":[{"value":"2022-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01717-22"}}