{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:45:51Z","timestamp":1791812751343,"version":"4.3.4"},"reference-count":113,"publisher":"American Society for Microbiology","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT2018-03004"],"award-info":[{"award-number":["PICT2018-03004"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012478","name":"Secretaria de Ciencia y Tecnolog\u00eda - Universidad Nacional de C\u00f3rdoba","doi-asserted-by":"publisher","award":["CONSOLIDAR 2018 & PIDTA-CONSOLIDAR 2023 No. PIP 33620230100625CB"],"award-info":[{"award-number":["CONSOLIDAR 2018 & PIDTA-CONSOLIDAR 2023 No. PIP 33620230100625CB"]}],"id":[{"id":"10.13039\/100012478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Chlamydia trachomatis<\/jats:italic>\n                      is an obligate intracellular pathogen that can reversibly halt replication and developmental transitions in response to immunological or pharmacological stress, a phenomenon linked to chlamydial persistence. Although polymorphic membrane proteins (Pmps) are known adhesins, their broader roles in other pathogenesis-relevant processes remain poorly understood. Here, we characterized a\n                      <jats:italic toggle=\"yes\">pmpC-<\/jats:italic>\n                      null mutant generated by insertional mutagenesis and found that while PmpC is not essential for primary growth, it is required for the efficient transition from reticulate bodies to infectious elementary bodies during recovery from IFN\u03b3- and penicillin-induced stress. High-resolution microscopy and temporal expression analysis revealed that PmpC localizes to the bacterial periphery throughout the developmental cycle and is released into the lumen of pathogen-containing vacuoles (inclusions), suggesting a role beyond bacterial attachment to host cells. The absence of PmpC leads to clustered bacterial distribution and reduced bacterial mobility within the inclusion. These defects correlate with delayed cellular invasion and impaired dissemination to adjacent host cells. Notably, the significance of PmpC in penicillin-induced persistence was validated using an\n                      <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                      murine uterine horn model. Altogether, our findings reveal PmpC as a multifunctional virulence factor that mediates stress recovery, regulates bacterial distribution and dynamics within the inclusion, modulates early invasion and facilitates lateral spread, expanding its recognized role as an adhesin.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        <jats:italic toggle=\"yes\">Chlamydia trachomatis<\/jats:italic>\n                        is a leading cause of sexually transmitted infections and preventable blindness globally. A significant challenge in controlling chlamydial diseases is the ability of these bacteria to enter a reversibly non-replicating \u201cpersistent\u201d state to survive immune pressure, nutritional stress, or antibiotic treatment. In this study, we identify the surface protein PmpC as a multifunctional factor required for bacterial recovery from IFN\u03b3- and penicillin-induced stress, in both tissue culture and an\n                        <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                        murine model of uterine infection. Furthermore, we found that PmpC modulates invasion and bacterial spatial distribution within the inclusion. These findings uncover novel roles for PmpC as a virulence factor in\n                        <jats:italic toggle=\"yes\">C. trachomatis<\/jats:italic>\n                        infection.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.01773-26","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:00:32Z","timestamp":1791810032000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Loss of PmpC in\n                    <i>Chlamydia trachomatis<\/i>\n                    leads to altered bacterial development and impaired recovery from IFN\u03b3- and penicillin-induced stress"],"prefix":"10.1128","author":[{"given":"Ailen N.","family":"Anna","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"publisher"}],"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","place":["C\u00f3rdoba, Argentina"]},{"id":[{"id":"https:\/\/ror.org\/056tb7j80","id-type":"ROR","asserted-by":"publisher"}],"name":"Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba","place":["C\u00f3rdoba, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda E.","family":"Panzetta","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"publisher"}],"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","place":["C\u00f3rdoba, Argentina"]},{"id":[{"id":"https:\/\/ror.org\/056tb7j80","id-type":"ROR","asserted-by":"publisher"}],"name":"Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba","place":["C\u00f3rdoba, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria N.","family":"Bettucci Ferrero","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"publisher"}],"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","place":["C\u00f3rdoba, Argentina"]},{"id":[{"id":"https:\/\/ror.org\/056tb7j80","id-type":"ROR","asserted-by":"publisher"}],"name":"Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba","place":["C\u00f3rdoba, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Mar\u00edn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"publisher"}],"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","place":["C\u00f3rdoba, Argentina"]},{"id":[{"id":"https:\/\/ror.org\/056tb7j80","id-type":"ROR","asserted-by":"publisher"}],"name":"Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba","place":["C\u00f3rdoba, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belkys A.","family":"Maletto","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"publisher"}],"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","place":["C\u00f3rdoba, Argentina"]},{"id":[{"id":"https:\/\/ror.org\/056tb7j80","id-type":"ROR","asserted-by":"publisher"}],"name":"Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba","place":["C\u00f3rdoba, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego D.","family":"del Balzo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05sn8wf81","id-type":"ROR","asserted-by":"publisher"}],"name":"Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo","place":["Mendoza, Argentina"]},{"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Medicina y Biolog\u00eda Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","place":["Mendoza, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Alonso Bivou","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05sn8wf81","id-type":"ROR","asserted-by":"publisher"}],"name":"Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo","place":["Mendoza, Argentina"]},{"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Medicina y Biolog\u00eda Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","place":["Mendoza, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"Damiani","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05sn8wf81","id-type":"ROR","asserted-by":"publisher"}],"name":"Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo","place":["Mendoza, Argentina"]},{"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Medicina y Biolog\u00eda Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","place":["Mendoza, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Bastidas","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00py81415","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Integrative Immunobiology, Duke University School of Medicine","place":["Durham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0961-073X","authenticated-orcid":true,"given":"Raphael H.","family":"Valdivia","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00py81415","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Integrative Immunobiology, Duke University School of Medicine","place":["Durham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-7337","authenticated-orcid":true,"given":"H\u00e9ctor A.","family":"Saka","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"publisher"}],"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","place":["C\u00f3rdoba, Argentina"]},{"id":[{"id":"https:\/\/ror.org\/056tb7j80","id-type":"ROR","asserted-by":"publisher"}],"name":"Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba","place":["C\u00f3rdoba, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143304"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1674277"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-025-01102-5"},{"key":"e_1_3_5_5_2","unstructured":"WHO. 2025. Sexually transmitted infections (STIs). Key facts. on World Health Organization. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/sexually-transmitted-infections-(stis."},{"key":"e_1_3_5_6_2","unstructured":"WHO. 2026. Trachoma. Key facts. on World Health Organization. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/trachoma."},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199101000-00001"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.spid.2005.06.004"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir699"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328320a8ae"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6534a6"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000466"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000519"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/513844"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0303-4569.2003.00594.x"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02647.x"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/652395"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199207000-00001"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.9.815"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.03.043"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.30"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a010256"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2009.11.002"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07877.x"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12071302"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2025.2503423"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/652394"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2011.03.004"},{"key":"e_1_3_5_29_2","first-page":"1","volume-title":"Intracellular Pathogens I: Chlamydiales","author":"Byron EB","year":"2012","unstructured":"Byron EB. 2012. Chlamydia infection and epidemiology, p 1\u201326. In Intracellular Pathogens I: Chlamydiales. ASM Press, Washington, DC."},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03101"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2026.1783835"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00534"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00203-17"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.036566-0"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00394"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28569-1"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02719-22"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1214017"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.02.004"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2006.12.003"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.01269-21"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00513-22"},{"key":"e_1_3_5_43_2","first-page":"2919","article-title":"Effect of interferon on a primary conjunctival epithelial cell model of trachoma","volume":"32","author":"Rapoza PA","year":"1991","unstructured":"Rapoza PA, Tahija SG, Carlin JP, Miller SL, Padilla ML, Byrne GI. 1991. Effect of interferon on a primary conjunctival epithelial cell model of trachoma. Invest Ophthalmol Vis Sci 32:2919\u20132923.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.9.3998"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.9.3705-3711.1994"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17993"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00072"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.05.039"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.76721"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00483-22"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2008.00105.x"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007723"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69397-x"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.1.303-305.2001"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1514026112"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2012.07.017"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.48.6.437"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-4801-3.00109-0"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1089\/omi.1.1999.4.187"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0966-842x(01)02234-x"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2015.1111509"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.68.4.692-744.2004"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01389.x"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.4.2383-2389.2001"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9861(200202)2:2<164::aid-prot164>3.0.co;2-u"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-2-36"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03838.x"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000568"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005191"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01173-08"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.10.5473-5479.2000"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M116.061986"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.03.070"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.709724"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00756"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.58.8.2606-2615.1992"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.03.014"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117884109"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1542-9"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057090"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.13.4.1103-1109.1976"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002258"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.10.3013-3019.1998"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.7.2172"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2009.08.022"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01507-1"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.12.002"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2011.01598.x"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.186"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.931653"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1185571"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix155"},{"key":"e_1_3_5_93_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.9.5423-5429.2001"},{"key":"e_1_3_5_94_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.6.2976-2981.2002"},{"key":"e_1_3_5_95_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01487-05"},{"key":"e_1_3_5_96_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02104-05"},{"key":"e_1_3_5_97_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05465.x"},{"key":"e_1_3_5_98_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00758-25"},{"key":"e_1_3_5_99_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102229108"},{"key":"e_1_3_5_100_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00356-16"},{"key":"e_1_3_5_101_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2535394100"},{"key":"e_1_3_5_102_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01686-14"},{"key":"e_1_3_5_103_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00293-09"},{"key":"e_1_3_5_104_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1519883"},{"key":"e_1_3_5_105_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003325"},{"key":"e_1_3_5_106_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00996.x"},{"key":"e_1_3_5_107_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008178107"},{"key":"e_1_3_5_108_2","doi-asserted-by":"publisher","DOI":"10.3791\/4036"},{"key":"e_1_3_5_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.09.015"},{"key":"e_1_3_5_110_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00943"},{"key":"e_1_3_5_111_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1386343"},{"key":"e_1_3_5_112_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13030553"},{"key":"e_1_3_5_113_2","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftae019"},{"key":"e_1_3_5_114_2","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftab012"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01773-26","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01773-26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:00:36Z","timestamp":1791810036000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.01773-26"}},"subtitle":[],"editor":[{"given":"Ryan","family":"Rego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":113,"alternative-id":["10.1128\/spectrum.01773-26"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.01773-26","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]},"assertion":[{"value":"2026-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01773-26"}}