{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:39:03Z","timestamp":1759883943706,"version":"build-2065373602"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              The\n              <jats:italic toggle=\"yes\">Acinetobacter calcoaceticus-baumannii<\/jats:italic>\n              complex includes high-priority, multidrug-resistant pathogens for which novel antibiotics are urgently needed. Many bacterial strains from this complex harbor a so-called\n              <jats:italic toggle=\"yes\">iac<\/jats:italic>\n              gene cluster that codes for the catabolism of indole-3-acetic acid (IAA). Here, we demonstrate that possession and expression of\n              <jats:italic toggle=\"yes\">iac<\/jats:italic>\n              genes represent an Achilles\u2019 heel for\n              <jats:italic toggle=\"yes\">Acinetobacter<\/jats:italic>\n              species, which can be exploited to suppress bacterial growth by treatment with IAA and its analog 5-chloro-IAA.\n            <\/jats:p>\n            <jats:sec>\n              <jats:title>IMPORTANCE<\/jats:title>\n              <jats:p>\n                <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                is a deadly bacterial pathogen and one of the leading causes of hospital-acquired infections worldwide. It is also known for its resistance to many antibiotics currently available. In this study, we show that\n                <jats:italic toggle=\"yes\">Acinetobacter<\/jats:italic>\n                bacteria choke on a mixture of IAA and 5-chloro-IAA, offering a path to the discovery and development of a novel drug treatment.\n              <\/jats:p>\n            <\/jats:sec>\n          <\/jats:sec>","DOI":"10.1128\/spectrum.01858-25","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:00:25Z","timestamp":1756990825000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Growth inhibition of\n            <i>Acinetobacter<\/i>\n            by 5-chloro-indole-3-acetic acid"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2317-2895","authenticated-orcid":true,"given":"Tyler S.","family":"Laird","sequence":"first","affiliation":[{"name":"Department of Plant Pathology, University of California Davis","place":["Davis, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Gaeni","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, University of California Davis","place":["Davis, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8376-4553","authenticated-orcid":true,"given":"Johan H. 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