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The wide geographic spread and the increasing trend of highly resistant\n            <jats:italic>Pfdhfr<\/jats:italic>\n            genes between 2016 and 2021 found in our study are worrisome and emphasize the urgency to monitor their updated status in central Africa.\n          <\/jats:p>","DOI":"10.1128\/spectrum.02005-22","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T13:03:29Z","timestamp":1663592609000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Molecular Determinants of Sulfadoxine-Pyrimethamine Resistance in Plasmodium falciparum Isolates from Central Africa between 2016 and 2021: Wide Geographic Spread of Highly Mutated\n            <i>Pfdhfr<\/i>\n            and\n            <i>Pfdhps<\/i>\n            Alleles"],"prefix":"10.1128","volume":"10","author":[{"given":"Xiaoxiao","family":"Wang","sequence":"first","affiliation":[{"name":"Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyi","family":"Lu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3717-3055","authenticated-orcid":true,"given":"Wei","family":"Ruan","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"World malaria report.","author":"World Health Organization","year":"2021","unstructured":"World Health Organization. 2021. 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