{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:26:44Z","timestamp":1790270804038,"version":"4.1.0"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"crossref","award":["201908520049"],"award-info":[{"award-number":["201908520049"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013314","name":"111 Project","doi-asserted-by":"crossref","award":["D20009"],"award-info":[{"award-number":["D20009"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["no. 32060034"],"award-info":[{"award-number":["no. 32060034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008862","name":"China National Tobacco Corporation","doi-asserted-by":"crossref","award":["[110202101048 (LS-08)]"],"award-info":[{"award-number":["[110202101048 (LS-08)]"]}],"id":[{"id":"10.13039\/501100008862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"China\u2013Ukraine Inthergovermental Exchange Project","award":["8"],"award-info":[{"award-number":["8"]}]},{"name":"Guizhou High-leval Innovative Talent Category","award":["qiankeherencai-GCC[2022]036-1"],"award-info":[{"award-number":["qiankeherencai-GCC[2022]036-1"]}]},{"name":"Foregin Experts Progect Category","award":["(G2021038009L)"],"award-info":[{"award-number":["(G2021038009L)"]}]},{"name":"International Science and Technology Cooperation Base of Guizhou Province","award":["[2020]4101"],"award-info":[{"award-number":["[2020]4101"]}]},{"name":"Guizhou Scientific Plan Project","award":["[2020]4Y220"],"award-info":[{"award-number":["[2020]4Y220"]}]},{"name":"Guizhou Provincial Academician Workstation of Microbiology and Health","award":["No. [2020]4004"],"award-info":[{"award-number":["No. [2020]4004"]}]},{"name":"Talent Base Project of Guizhou Province China","award":["[FCJD2018-22]"],"award-info":[{"award-number":["[FCJD2018-22]"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2024,4,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              The present paper includes a meta-analysis of literature data on 318 species of fungi belonging to 34 orders in their response to 8 antifungal agents (amphotericin B, caspofungin, fluconazole, itraconazole, ketoconazole, posaconazole, terbinafine, and voriconazole). Main trends of MIC results at the ordinal level were visualized. European Committee on Antimicrobial Susceptibility Testing and Clinical &amp; Laboratory Standards Institute (CLSI) clinical breakpoints were used as the staff gauge to evaluate MIC values ranging from resistance to susceptibility, which were subsequently compared with a phylogenetic tree of the fungal kingdom. Several orders (\n              <jats:italic>Hypocreales, Microascales<\/jats:italic>\n              , and\n              <jats:italic>Mucorales<\/jats:italic>\n              ) invariably showed resistance. Also the basidiomycetous orders\n              <jats:italic>Agaricales, Polyporales, Sporidiales, Tremellales<\/jats:italic>\n              , and\n              <jats:italic>Trichosporonales<\/jats:italic>\n              showed relatively high degrees of azole multi-resistance, while elsewhere in the fungal kingdom, including orders with numerous pathogenic and opportunistic species, that is,\n              <jats:italic>Onygenales, Chaetothyiales, Sordariales<\/jats:italic>\n              , and\n              <jats:italic>Malasseziales<\/jats:italic>\n              , in general were susceptible to azoles. In most cases, resistance vs susceptibility was consistently associated with phylogenetic distance, members of the same order showing similar behavior.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>A kingdom-wide the largest set of published wild-type antifungal data comparison were analyzed. Trends in resistance in taxonomic groups (monophyletic clades) can be compared with the phylogeny of the fungal kingdom, eventual relationships between fungus\u2013drug interaction and evolution can be described.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/spectrum.02127-23","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T14:01:30Z","timestamp":1709733690000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Evolutionary trends in antifungal resistance: a meta-analysis"],"prefix":"10.1128","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3867-2210","authenticated-orcid":false,"given":"Xueke","family":"Niu","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou &amp; Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China"},{"name":"Center of Expertise in Mycology of Radboud University Medical Center\/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-2647","authenticated-orcid":true,"given":"Abdullah M. S.","family":"Al-Hatmi","sequence":"additional","affiliation":[{"name":"Center of Expertise in Mycology of Radboud University Medical Center\/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands"},{"name":"Natural &amp; Medical Science Research Center, University of Nizwa, Nizwa, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana G.","family":"Vitale","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET), Buenos Aires, Argentina"},{"name":"Unidad de Parasitolog\u00eda, Sector Micolog\u00eda, Hospital J.M. Ramos Mej\u00eda, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Lackner","sequence":"additional","affiliation":[{"name":"Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0155-8113","authenticated-orcid":true,"given":"Sarah A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Center of Expertise in Mycology of Radboud University Medical Center\/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8600-9860","authenticated-orcid":true,"given":"Paul E.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Center of Expertise in Mycology of Radboud University Medical Center\/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6033-447X","authenticated-orcid":true,"given":"Yingqian","family":"Kang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou &amp; Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-257X","authenticated-orcid":true,"given":"Sybren","family":"de Hoog","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou &amp; Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China"},{"name":"Center of Expertise in Mycology of Radboud University Medical Center\/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.1.4.349"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1999.tb01397.x"},{"key":"e_1_3_3_4_2","first-page":"974","article-title":"Prevention of fungal infections in the immunocompromised host","volume":"4","author":"Mahfouz T","year":"2003","unstructured":"Mahfouz T, Anaissie E. 2003. Prevention of fungal infections in the immunocompromised host. Curr Opin Investig Drugs 4:974\u2013990.","journal-title":"Curr Opin Investig Drugs"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/380643"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/20499361211039050"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_3_3_8_2","volume-title":"Atlas of clinical fungi: the ultimate benchtool for diagnostics. introductions, lower fungi, basidiomycetes, yeasts, filamentous ascomycetes AB. part \u0391","author":"de Hoog GS","year":"2021","unstructured":"de Hoog GS, de Guarro J, Gen\u00e9 JG, Ahmed SA, Al Hatmi AMS, Figueras MJ, Vitale RG. 2021. Atlas of clinical fungi: the ultimate benchtool for diagnostics. introductions, lower fungi, basidiomycetes, yeasts, filamentous ascomycetes AB. part \u0391. Foundation Atlas of Clinical Fungi."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3114\/sim.2008.61.14"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2017-0124"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.05.003"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.90"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof2020018"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.3.556-569.2005"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3892"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/194589240401800202"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00292"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa530"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-020-00462-9"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2020.07.001"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix179"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2008.00083.x"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00020-09"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2507.181625"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/ppa.13429"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.08.010"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2016.1110142"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201802416"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.730297"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70265-8"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b02728"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12896"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.014"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00566-08"},{"key":"e_1_3_3_36_2","volume-title":"Performance standards for antifungal susceptibility testing of filamentous fungi","author":"CLSI","year":"2020","unstructured":"CLSI. 2020. Performance standards for antifungal susceptibility testing of filamentous fungi. 2nd ed. CLSI supplement M61.","edition":"2"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1109\/MCSE.2007.55"},{"key":"e_1_3_3_38_2","volume-title":"Performance standards for antifungal susceptibility testing of yeasts","author":"CLSI","year":"2020","unstructured":"CLSI. 2020. Performance standards for antifungal susceptibility testing of yeasts. 2nd ed. CLSI supplement M60.","edition":"2"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4_9"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst010"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1145\/2335755.2335836"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu033"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.8.2353-2355.1998"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-012-0125-7"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2018-0059"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00485-17"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019570"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00318-20"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2018.02.005"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.091208.073435"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.21931\/RB\/2021.06.01.28"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2018.10.017"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-014-9813-x"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0013-2020"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00014-07"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01503-19"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02127-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02127-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T15:09:39Z","timestamp":1712070579000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.02127-23"}},"subtitle":[],"editor":[{"given":"Rebecca S.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4,2]]}},"alternative-id":["10.1128\/spectrum.02127-23"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.02127-23","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,2]]},"assertion":[{"value":"2023-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02127-23"}}