{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:14:21Z","timestamp":1777331661647,"version":"3.51.4"},"reference-count":11,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2022,10,26]]},"abstract":"<jats:p>Monoclonal antibody bitherapies (MAbs) are commonly prescribed to treat severe SARS-CoV-2-positive patients, and the rapid growth of resistance mutation emergence is alarming globally. To explore this issue, we conducted both clinical and genomic analyses of SARS-CoV-2 in a series of patients treated in 2021.<\/jats:p>","DOI":"10.1128\/spectrum.02152-22","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T13:06:44Z","timestamp":1663679204000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Dual Monoclonal Antibodies on Sars-Cov-2 Alpha and Delta Variants: Clinical and Virological Efficacy"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2196-6141","authenticated-orcid":true,"given":"Valentine Marie","family":"Ferr\u00e9","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME, Paris, France"},{"name":"Virology Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Peiffer-Smadja","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME, Paris, France"},{"name":"Infectious Disease Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Kramer","sequence":"additional","affiliation":[{"name":"Pharmacy Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3024-5928","authenticated-orcid":true,"given":"Romain","family":"Copp\u00e9e","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A\u00efcha","family":"Kante","sequence":"additional","affiliation":[{"name":"Infectious Disease Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaux","family":"Debarge","sequence":"additional","affiliation":[{"name":"Pharmacy Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Choquet","sequence":"additional","affiliation":[{"name":"Emergency Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibault","family":"Saint Joannis","sequence":"additional","affiliation":[{"name":"Virology Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-3320","authenticated-orcid":true,"given":"Donia","family":"Bouzid","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME, Paris, France"},{"name":"Emergency Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Messika","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, INSERM U1152 PHERE, Paris, France"},{"name":"Pneumology Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"},{"name":"Paris Transplant Group, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Le Grand","sequence":"additional","affiliation":[{"name":"Pharmacy Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Thy","sequence":"additional","affiliation":[{"name":"Infectious Disease Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, EA 7323\u2013Pharmacology and Therapeutic Evaluation in Children and Pregnant Women, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solen","family":"Kern\u00e9is","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME, Paris, France"},{"name":"Equipe de Pr\u00e9vention du Risque Infectieux (EPRI), AP-HP, H\u00f4pital Bichat, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Descamps","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME, Paris, France"},{"name":"Virology Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9279-5538","authenticated-orcid":true,"given":"Benoit","family":"Visseaux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME, Paris, France"},{"name":"Virology Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jade","family":"Ghosn","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME, Paris, France"},{"name":"Infectious Disease Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/v13081642"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102685"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2109682"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-021-00525-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2710.211538"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100255"},{"key":"e_1_3_2_8_2","unstructured":"European Medicines Agency. 2021. Assessment report: Eli Lilly and Company Limited use of bamlanivimab and etesevimab for the treatment of COVID-19. https:\/\/www.ema.europa.eu\/en\/documents\/referral\/eli-lilly-company-limited-antibody-combination-bamlanivimab\/etesevimab-covid19-article-53-procedure-assessment-report_en.pdf."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.07.012"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009772"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2120219"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01690-7"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02152-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02152-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T14:03:16Z","timestamp":1666792996000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.02152-22"}},"subtitle":[],"editor":[{"given":"Leiliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10,26]]}},"alternative-id":["10.1128\/spectrum.02152-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.02152-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]},"assertion":[{"value":"2022-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02152-22"}}