{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:29:01Z","timestamp":1785432541575,"version":"3.56.0"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Colistin is a last-resort treatment for highly drug-resistant bacterial infections. Of 47,184\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      isolates collected from 2017 to 2022 in Canada from human and animal\/food sources, mobile colistin resistance (\n                      <jats:italic toggle=\"yes\">mcr<\/jats:italic>\n                      ) variants conferring colistin resistance were detected exclusively in humans (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 15). These variants were\n                      <jats:italic toggle=\"yes\">mcr<\/jats:italic>\n                      -1.1 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 7),\n                      <jats:italic toggle=\"yes\">mcr<\/jats:italic>\n                      -3.1 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5),\n                      <jats:italic toggle=\"yes\">mcr<\/jats:italic>\n                      -3.2 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2), and\n                      <jats:italic toggle=\"yes\">mcr<\/jats:italic>\n                      -1.2 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1). The most common\n                      <jats:italic toggle=\"yes\">mcr<\/jats:italic>\n                      -containing serotypes were I 4,[5],12:i:- (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 8) and Typhimurium (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 3). The proportion of\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      carrying\n                      <jats:italic toggle=\"yes\">mcr<\/jats:italic>\n                      genes remains low in Canada (0.03%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>\n                      Colistin can be used in combination with other drugs as salvage therapy for extensively drug-resistant infections. If mobile colistin resistance (\n                      <jats:italic toggle=\"yes\">mcr<\/jats:italic>\n                      ) becomes widely disseminated in\n                      <jats:italic toggle=\"yes\">Enterobacterales<\/jats:italic>\n                      , colistin will no longer be an option for salvage therapy in otherwise untreatable infections. While colistin is not commonly used to treat human\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      infections,\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      represents an important reservoir of\n                      <jats:italic toggle=\"yes\">mcr<\/jats:italic>\n                      genes that may be transmitted to other gram-negative bacteria. Our aim was to determine the occurrence of\n                      <jats:italic toggle=\"yes\">mcr<\/jats:italic>\n                      genes in\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      isolates collected from humans, food animals, and retail meats in Canada.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.02156-24","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T09:00:57Z","timestamp":1747645257000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["One Health study of mobile colistin resistance (\n                    <i>mcr<\/i>\n                    ) in\n                    <i>Salmonella enterica<\/i>\n                    in Canada, 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