{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:20:59Z","timestamp":1790882459869,"version":"4.1.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100017380","name":"Science and Technology Foundation of Shenzhen City","doi-asserted-by":"publisher","award":["20170410160041091"],"award-info":[{"award-number":["20170410160041091"]}],"id":[{"id":"10.13039\/100017380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005847","name":"FHB | Health and Medical Research Fund","doi-asserted-by":"publisher","award":["14130402"],"award-info":[{"award-number":["14130402"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2022,4,27]]},"abstract":"<jats:p>\n            The transferable mechanisms of quinolone resistance (TMQR) gene,\n            <jats:italic>oqxAB<\/jats:italic>\n            , has been widely detected in\n            <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n            and is commonly associated with\n            <jats:italic>aac(6\u2032)-Ib-cr<\/jats:italic>\n            . It is thought to be associated with fluoroquinolone resistance, while its ancestor gene from\n            <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n            is not. This study evaluated the actual role of the plasmid-borne\n            <jats:italic>oqxAB<\/jats:italic>\n            genes in\n            <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n            and showed that it was not able to mediate intermediated resistance to fluoroquinolone and only did so when it coexisted with\n            <jats:italic>aac(6\u2032)-Ib-cr<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/spectrum.02170-21","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T13:00:32Z","timestamp":1647954032000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Transcriptional Regulation and Functional Characterization of the Plasmid-Borne\n            <i>oqxAB<\/i>\n            Genes in\n            <i>Salmonella<\/i>\n            Typhimurium"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1617-2881","authenticated-orcid":true,"given":"Bill Kwan-wai","family":"Chan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, the Hong Kong Polytechnic University, Kowloon, Hong Kong"},{"name":"Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Ho-yin","family":"Wong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, the Hong Kong Polytechnic University, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward Wai-chi","family":"Chan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, the Hong Kong Polytechnic University, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3526-7808","authenticated-orcid":true,"given":"Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/497599"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06191-11"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00007-19"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00310-15"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plasmid.2008.03.003"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01555-16"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073947"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01574-08"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00456-12"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004627"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2017.10.005"},{"key":"e_1_3_3_13_2","volume-title":"Characterization the role of OqxAB in Salmonella virulence and antimicrobial resistance.","author":"Wong MH","year":"2018","unstructured":"Wong MH, Lin D, Chan EW. 2018. Characterization the role of OqxAB in Salmonella virulence and antimicrobial resistance. Health and Medical Research Fund, Hong Kong. https:\/\/rfs2.fhb.gov.hk\/app\/fundedsearch\/projectdetail.xhtml?id=1667."},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-3-12"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10111383"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05509-11"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058449"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00521"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2164(09)69001-8"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt432"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj014"},{"key":"e_1_3_3_22_2","volume-title":"Performance standards for antimicrobial susceptibility testing","author":"CLSI","year":"2021","unstructured":"CLSI. 2021. Performance standards for antimicrobial susceptibility testing, 31st ed CLSI guideline M100. CLSI, Wayne, PA.","edition":"31"},{"key":"e_1_3_3_23_2","first-page":"61","volume-title":"Metagenomics and its applications in agriculture, biomedicine and environmental studies","author":"Salamov VSA","year":"2011","unstructured":"Salamov VSA, Solovyevand A. 2011. Automatic annotation of microbial genomes and metagenomic sequences, p 61\u201378. In Li RW, (ed) Metagenomics and its applications in agriculture, biomedicine and environmental studies. Nova Science Publishers, Hauppauge, NY."},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120163297"}],"container-title":["Microbiology Spectrum"],"original-title":[],"contributor":[{"given":"Hongning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]}],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02170-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02170-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T13:36:02Z","timestamp":1651066562000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.02170-21"}},"subtitle":[],"editor":[{"given":"Sandeep","family":"Tamber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,27]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4,27]]}},"alternative-id":["10.1128\/spectrum.02170-21"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.02170-21","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,27]]},"assertion":[{"value":"2021-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02170-21"}}