{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:29:18Z","timestamp":1787614158140,"version":"build-2736575974"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1I1A3A04037486"],"award-info":[{"award-number":["2021R1I1A3A04037486"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2022R1C1C2006146"],"award-info":[{"award-number":["2022R1C1C2006146"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2021R1A2C1008368"],"award-info":[{"award-number":["2021R1A2C1008368"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2014R1A6A1031189"],"award-info":[{"award-number":["2014R1A6A1031189"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2022,10,26]]},"abstract":"<jats:p>\n            Persistence in chronic infections by\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            is due to its ability of biofilm formation that endures conventional antifungals and host immune systems. Hence, the inhibition of biofilm formation and virulence characteristics is another mean of addressing infections. This study is a distinctive one since 18 hydroquinone analogues were screened and TCHQ efficiently inhibited the biofilm formation by\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            with significantly changed expressional profile of hyphae-forming and biofilm-related genes. The antibiofilm efficacy was confirmed using a porcine skin model and chemical toxicity was investigated using plant seed germination and nematode models.\n          <\/jats:p>","DOI":"10.1128\/spectrum.02536-22","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T14:00:20Z","timestamp":1664805620000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Hydroquinones Including Tetrachlorohydroquinone Inhibit Candida albicans Biofilm Formation by Repressing Hyphae-Related Genes"],"prefix":"10.1128","volume":"10","author":[{"given":"Yong-Guy","family":"Kim","sequence":"first","affiliation":[{"name":"School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunyoung","family":"Park","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar Kiran","family":"Khadke","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Jin","family":"Shim","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1383-1682","authenticated-orcid":true,"given":"Jintae","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.4.633-638.2005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2636"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00028"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(00)01913-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389203720666190722152415"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2007.24"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3013"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.23"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00447"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01670.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-019-03067-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25215015"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e07021"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22091527"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01309"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja301056a"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2174\/138945010790711996"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-014-9283-4"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10040565"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00340-06"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020063"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00194-06"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/156.1.31"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00163-12"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000133"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27663-0"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2475"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.13268"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/08927014.2020.1730333"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.13710"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00033"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.153033"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.13864"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652015000700011"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1685"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(90)90322-m"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-012-4225-7"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02056-21"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2009.03.014"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14051047"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01330-22"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-409x(00)00129-0"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02536-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02536-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T13:57:06Z","timestamp":1666792626000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.02536-22"}},"subtitle":[],"editor":[{"given":"Renato","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10,26]]}},"alternative-id":["10.1128\/spectrum.02536-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.02536-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]},"assertion":[{"value":"2022-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02536-22"}}