{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:59:14Z","timestamp":1794261554404,"version":"4.9.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Cinical Research Project of the Shanghai Municipal Health Commission","award":["No. 202340254"],"award-info":[{"award-number":["No. 202340254"]}]},{"name":"Shanghai Hospital Development Center Foundation","award":["No. SHDC22023234"],"award-info":[{"award-number":["No. SHDC22023234"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2025,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n Eravacycline, a novel tetracycline antibiotic, may be an effective treatment option for\n Klebsiella pneumoniae<\/jats:italic>\n infections. We thus conducted an\n in vitro<\/jats:italic>\n susceptibility analysis for eravacycline in 211\n K. pneumoniae<\/jats:italic>\n isolates. Eravacycline achieved an overall susceptibility rate of 86% against\n K. pneumoniae<\/jats:italic>\n , and the sensitivity rates to carbapenem-susceptible\n Klebsiella pneumoniae<\/jats:italic>\n and carbapenem-resistant\n Klebsiella pneumoniae<\/jats:italic>\n (CRKP) strains were 100% and 84%, respectively. The combined drug sensitivity test\n in vitro<\/jats:italic>\n for eravacycline and polymyxin B demonstrated a synergistic effect in 20% of eravacycline-resistant CRKP strains.\n <\/jats:p>\n <\/jats:sec>\n \n IMPORTANCE<\/jats:title>\n \n Carbapenem-resistant\n Klebsiella pneumoniae<\/jats:italic>\n (CRKP) is a global priority pathogen due to its limited therapeutic options and high morbidity, which urgently needs new antibiotics that are not affected by common resistance mechanisms. As the next generation of fluorocycline antibiotics, eravacycline can circumvent the tetracycline-specific resistance pathways by its structural modifications, which may be a candidate antibiotic for CRKP infections. The present study evaluated the\n in vitro<\/jats:italic>\n activity of eravacycline against CRKP strains, including carbapenemase producers, and explored synergistic interactions with existing antibiotics. By determining the efficacy spectrum and combinatorial potential for eravacycline, this study will directly guide clinical strategies to combat infections caused by CRKP and optimize treatment regimens for high-risk populations.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1128\/spectrum.02564-24","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T10:49:17Z","timestamp":1748602157000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Antibacterial activity of eravacycline against\n Klebsiella pneumoniae<\/i>\n isolates: an\n in vitro<\/i>\n study"],"prefix":"10.1128","volume":"13","author":[{"given":"Yuanzhi","family":"Gong","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rc6as71","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Critical Care Medicine, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Liu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rc6as71","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Critical Care Medicine, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlou","family":"Zhu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rc6as71","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Critical Care Medicine, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikui","family":"Mu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rc6as71","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Critical Care Medicine, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlu","family":"Gao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rc6as71","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Critical Care Medicine, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jing","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rc6as71","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Critical Care Medicine, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-8778","authenticated-orcid":false,"given":"Yingying","family":"Du","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rc6as71","id-type":"ROR","asserted-by":"publisher"}],"name":"Intensive Care Medical Centre, Tongji Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3439-4696","authenticated-orcid":true,"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rc6as71","id-type":"ROR","asserted-by":"publisher"}],"name":"Intensive Care Medical Centre, Tongji Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0315-1"},{"key":"e_1_3_4_3_2","volume-title":"Antibiotic resistance threats in the United States, 2019","author":"CDC","year":"2019","unstructured":"CDC. 2019. Antibiotic resistance threats in the United States, 2019. U.S. Department of Health and Human Services, CDC, Atlanta, GA."},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12020234"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2023.01.017"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanmic.2024.07.010"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.106178"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.4237"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01067-3"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2024.2303028"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-021-01735-1"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001592"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2023.04.017"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2022.05.020"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S473546"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S396910"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01065-24"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2023.116006"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1039\/d1fd00036e"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuab049"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/membranes10080181"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44259-024-00051-6"}],"container-title":["Microbiology Spectrum"],"original-title":[],"contributor":[{"given":"Benno H.","family":"Ter Kuile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]},{"given":"Mor N.","family":"Lurie-Weinberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]}],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02564-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02564-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T09:05:34Z","timestamp":1751360734000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.02564-24"}},"subtitle":[],"editor":[{"given":"Andrea M.","family":"Prinzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1128\/spectrum.02564-24"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.02564-24","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02564-24"}}