{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:34:04Z","timestamp":1787016844229,"version":"build-2736575974"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR30159\/MED\/15\/188\/2018"],"award-info":[{"award-number":["BT\/PR30159\/MED\/15\/188\/2018"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2022,12,21]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Mycobacterium tuberculosis<\/jats:named-content>\n                    , the causative agent of TB is among the leading causes of death among infectious diseases in humans. This situation has worsened due to the failure of BCG vaccines and the increased number of cases with HIV-TB coinfections and drug-resistant strains.\n                  <\/jats:p>","DOI":"10.1128\/spectrum.02592-22","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T10:04:46Z","timestamp":1667210686000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["NSC19723, a Thiacetazone-Like Benzaldehyde Thiosemicarbazone Improves the Efficacy of TB Drugs\n                    <i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>"],"prefix":"10.1128","volume":"10","author":[{"given":"Padam","family":"Singh","sequence":"first","affiliation":[{"name":"Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srishti","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Kumar","family":"Agrahari","sequence":"additional","affiliation":[{"name":"Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Singh","sequence":"additional","affiliation":[{"name":"Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Chugh","sequence":"additional","affiliation":[{"name":"Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudagar","family":"Gurcha","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albel","family":"Singh","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Abrahams","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurdyal S.","family":"Besra","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailendra","family":"Asthana","sequence":"additional","affiliation":[{"name":"Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diwan S.","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2705-3826","authenticated-orcid":true,"given":"Ramandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.03.011"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a017822"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313865"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21498"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106753"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164571"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/35016103"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030466"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.09.036"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1998.tb12813.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.TBTB2-0027-2016"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00272-17"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1228980"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1167498"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01063-15"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09657"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171583"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05708-11"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01476-12"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01601-09"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl227"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01158-15"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.12.56"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.11.011"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/358591a0"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5347.98"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.2.1.29"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1170027pa"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx050328b"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/id500032q"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00162"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.17.9677"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062100"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-66-3-379"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.03051"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a017863"},{"key":"e_1_3_3_38_2","first-page":"933","article-title":"In vitro activity of thiacetazone on mycobacterial species belonging to the Mycobacterium tuberculosis complex","volume":"6","author":"Abate G","year":"2002","unstructured":"Abate G, Koivula T, Hoffner SE. 2002. In vitro activity of thiacetazone on mycobacterial species belonging to the Mycobacterium tuberculosis complex. Int J Tuberc Lung Dis 6:933\u2013935.","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2683"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00158"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2261"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-9792(08)70038-6"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12005"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138253"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704132104"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01972-12"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.6.1349"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.360-362.2003"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.76.895.259"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112772"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg301"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00969-17"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06957.x"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2015.6"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.9b01859"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1039\/d1ra06149f"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02592-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02592-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T09:44:11Z","timestamp":1671615851000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.02592-22"}},"subtitle":[],"editor":[{"given":"Joanna B.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12,21]]}},"alternative-id":["10.1128\/spectrum.02592-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.02592-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,21]]},"assertion":[{"value":"2022-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02592-22"}}