{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:01:04Z","timestamp":1790366464425,"version":"4.1.0"},"reference-count":57,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072297"],"award-info":[{"award-number":["82072297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2022,12,21]]},"abstract":"<jats:p>\n            In this study, the synergistic antibacterial and antibiofilm effects of the traditional herb\n            <jats:named-content content-type=\"genus-species\">C. ambrosioides<\/jats:named-content>\n            L. and the classic antibiotic penicillin G on MRSA provide a potential strategy to deal with the rapid development of MRSA antibiotic resistance. This study also provides a theoretical basis for further optimizing the combined effect of kaempferol rhamnosides, quercetin, and penicillin G and exploring anti-MRSA biofilm infection research with SarA and \u03c3B as drug targets.\n          <\/jats:p>","DOI":"10.1128\/spectrum.02782-22","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T14:00:30Z","timestamp":1668088830000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Global Downregulation of Penicillin Resistance and Biofilm Formation by MRSA Is Associated with the Interaction between Kaempferol Rhamnosides and Quercetin"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2894-8250","authenticated-orcid":true,"given":"Xinlong","family":"He","sequence":"first","affiliation":[{"name":"Department of Pathogenic Biology, School of Medicine, Yangzhou University, Yangzhou, People\u2019s Republic of China"},{"name":"Affiliated Hospital of Yangzhou University, Yangzhou, People\u2019s Republic of China"},{"name":"Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, People\u2019s Republic of China"},{"name":"Jiangsu Key Laboratory of Experimental &amp; Translational Non-coding RNA Research, School of Medicine, Yangzhou University, Yangzhou, People\u2019s Republic of China"},{"name":"Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology, School of Medicine, Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchao","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology, School of Medicine, Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Bao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lin","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Bao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiwang","family":"Chang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changshui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology, School of Medicine, Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology, School of Medicine, Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology, School of Medicine, Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingshan","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, People\u2019s Republic of China"},{"name":"Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology, School of Medicine, Yangzhou University, Yangzhou, People\u2019s Republic of China"},{"name":"Affiliated Hospital of Yangzhou University, Yangzhou, People\u2019s Republic of China"},{"name":"Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, People\u2019s Republic of China"},{"name":"Jiangsu Key Laboratory of Experimental &amp; Translational Non-coding RNA Research, School of Medicine, Yangzhou University, Yangzhou, People\u2019s Republic of China"},{"name":"Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis527"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1946.tb33336.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5219.124-a"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00134-14"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2003"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2011.09.019"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1318"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2017.09.016"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13634"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2019.06.007"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.10.5427-5433.1999"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/006031-0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115006109"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.2.5.17724"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-89779-2.00001-6"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-3120-7_17"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2112"},{"key":"e_1_3_3_19_2","first-page":"989","article-title":"Volatile constituents and antibacterial screening of the essential oil of Chenopodium ambrosioides L. growing in Nigeria","volume":"4","author":"Owolabi MS","year":"2009","unstructured":"Owolabi MS, Lajide L, Oladimeji MO, Setzer WN, Palazzo MC, Olowu RA, Ogundajo A. 2009. Volatile constituents and antibacterial screening of the essential oil of Chenopodium ambrosioides L. growing in Nigeria. Nat Prod Commun 4:989\u2013992.","journal-title":"Nat Prod Commun"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2006.10.017"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2013.10.007"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.988714"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0031-9422(99)00525-7"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00571"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02263"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3357-3363.2000"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)84689-0"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.5352\/JLS.2017.27.4.476"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200500732"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4221-00112"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00046-11"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00383-08"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.1.488-496.2006"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2006.01.042"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.08.016"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.29033-0"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.24.7341-7353.2001"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00463-16"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.13.4085-4099.2004"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00364-10"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.10.3029-3037.2004"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.08.005"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.17.5171-5179.2001"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01036-08"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01514-08"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.8.2635-2643.2003"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.7.1794-1801.2000"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.3.813-821.2005"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1507.07091"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002626"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv319"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00167-08"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10040428"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.07.004"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01768-21"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.2.345"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S276970"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2022.2034931"}],"container-title":["Microbiology Spectrum"],"original-title":[],"contributor":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2014-2271","authenticated-orcid":false,"given":"Mahadi","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]}],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02782-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.02782-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T14:42:03Z","timestamp":1671633723000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.02782-22"}},"subtitle":[],"editor":[{"given":"Cezar M.","family":"Khursigara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12,21]]}},"alternative-id":["10.1128\/spectrum.02782-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.02782-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,21]]},"assertion":[{"value":"2022-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02782-22"}}