{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:18:38Z","timestamp":1784042318742,"version":"3.55.0"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/AuthorWarrantyLicense.v1"},{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:p>\n            <jats:italic>Scedosporium<\/jats:italic>\n            and\n            <jats:italic>Lomentospora<\/jats:italic>\n            infections are notoriously hard to treat as these organisms can be resistant to numerous antifungals. The manuscript contributes to our knowledge of the activity of the new antifungal agent olorofim and comparator agents against\n            <jats:italic>Lomentospora<\/jats:italic>\n            and against\n            <jats:italic>Scedosporium<\/jats:italic>\n            isolates that have been molecularly identified to the species level. The efficacy of olorofim against all species of\n            <jats:italic>Scedosporium<\/jats:italic>\n            and\n            <jats:italic>Lomentospora<\/jats:italic>\n            was confirmed.\n          <\/jats:p>","DOI":"10.1128\/spectrum.02789-22","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T14:06:25Z","timestamp":1673445985000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["<i>In Vitro<\/i>\n            Activity of the Novel Antifungal Olorofim against\n            <i>Scedosporium<\/i>\n            and\n            <i>Lomentospora prolificans<\/i>"],"prefix":"10.1128","volume":"11","author":[{"given":"Ourania","family":"Georgacopoulos","sequence":"first","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2551-015X","authenticated-orcid":true,"given":"Natalie","family":"Nunnally","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Law","sequence":"additional","affiliation":[{"name":"F2G Ltd., Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Birch","sequence":"additional","affiliation":[{"name":"F2G Ltd., Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Berkow","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4383-5994","authenticated-orcid":true,"given":"Shawn R.","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx113"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00039-07"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2020.1705787"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100960050011"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01122-07"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03211-14"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2018.1514366"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13067"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05910-11"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05414-11"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof6030122"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608304113"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx161"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx177"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx065"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00999-18"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01527-20"},{"key":"e_1_3_2_19_2","article-title":"In vitro activity of novel antifungal olorofim against filamentous fungi and comparison to eight other antifungal agents","volume":"7","author":"Georgacopoulos O","year":"2021","unstructured":"Georgacopoulos O, Nunnally NS, Ransom EM, Law D, Birch M, Lockhart SR, Berkow EL. 2021. In vitro activity of novel antifungal olorofim against filamentous fungi and comparison to eight other antifungal agents. J Fungi (Basel) 7.","journal-title":"J Fungi (Basel)"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa562"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.106105"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00434-21"},{"key":"e_1_3_2_23_2","volume-title":"abstr ECCMID","author":"Tio S","year":"2020","unstructured":"Tio S, Thursky Y, Ng C, Rex J, Carney D, Slavin M. 2020. Olorofim for a case of severe disseminated Lomentospora prolificans infection, abstr ECCMID."},{"key":"e_1_3_2_24_2","volume-title":"abstr ECCMID","author":"Chen S","year":"2020","unstructured":"Chen S, Joshi RN, Cunneen S, Cornelissen K, Rex J, Heath CH, Harvey E. 2020. A case of Lomentospora prolificans treated with the novel antifungal olorofim, abstr ECCMID."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802524506"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12465"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa351"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2009.140142"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.funbio.2015.09.003"},{"key":"e_1_3_2_30_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of filamentous fungi","author":"Institute CaLS","year":"2017","unstructured":"Institute CaLS. 2017. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi, 3rd edition. 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