{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:42:37Z","timestamp":1792003357713,"version":"4.4.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100016275","name":"Seoul National University Bundang Hospital","doi-asserted-by":"crossref","award":["02-2023-0010"],"award-info":[{"award-number":["02-2023-0010"]}],"id":[{"id":"10.13039\/100016275","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2024,2,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In 2015,\n            <jats:italic>Staphylococcus argenteus<\/jats:italic>\n            and\n            <jats:italic>Staphylococcus schweitzeri<\/jats:italic>\n            were proposed as new species, distinct from\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            and collectively referred to as the\n            <jats:italic>S. aureus<\/jats:italic>\n            complex. However, no clinical reports of these new species exist in Korea. Upon the application of matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for all bloodstream isolates since September 2022,\n            <jats:italic>S. argenteus<\/jats:italic>\n            was identified in one patient. Therefore, we aimed to search for new species among the archives of the\n            <jats:italic>S. aureus<\/jats:italic>\n            bacteremia cohort and describe their clinical and microbiological characteristics. Among the 691 archived\n            <jats:italic>S. aureus<\/jats:italic>\n            isolates between 2012 and 2018, one was identified as\n            <jats:italic>S. argenteus<\/jats:italic>\n            via MALDI-TOF MS. Both\n            <jats:italic>S. argenteus<\/jats:italic>\n            isolates (one in 2022) were obtained from patients with extensive pneumonia accompanied by bacteremia and both cases had fatal outcomes. They harbored multiple virulence genes (\n            <jats:italic>clfA, clfB, fnbpA, sdrC, sdrD, sdrE, bbp, cna, see, seg, sei, blaZ, fnbpB,<\/jats:italic>\n            and\n            <jats:italic>map<\/jats:italic>\n            ) but did not harbor\n            <jats:italic>mecA<\/jats:italic>\n            and\n            <jats:italic>pvl<\/jats:italic>\n            . No matched sequence type (ST) was found in either isolate, and both\n            <jats:italic>S. argenteus<\/jats:italic>\n            isolates were closely related to ST1594, ST1593, ST1793, and ST1303, which belonged to\n            <jats:italic>S. argenteus. S. argenteus<\/jats:italic>\n            accounted for &lt;1% of the\n            <jats:italic>S. aureus<\/jats:italic>\n            complex but had clinical characteristics similar to\n            <jats:italic>S. aureus<\/jats:italic>\n            . Therefore, clinicians should be aware of these factors to avoid misidentifying these strains as coagulase-negative staphylococci, and appropriate reporting is required to minimize confusion.\n          <\/jats:p>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>\n              <jats:italic>Staphylococcus argenteus<\/jats:italic>\n              , a member of\n              <jats:italic>Staphylococcus aureus<\/jats:italic>\n              complex, has been reported as an important pathogen that causes clinically invasive infections in humans similar to\n              <jats:italic>S. aureus<\/jats:italic>\n              . Clinical isolates of\n              <jats:italic>S. argenteus<\/jats:italic>\n              have been reported across the world, showing a large geographical difference in prevalence and genomic profile. However, there have been no clinical reports regarding this new species in Korea. This is the first report to investigate the clinical and genetic characteristics of\n              <jats:italic>S. argenteus<\/jats:italic>\n              identified in patients with bacteremia, and the proportion of\n              <jats:italic>S. argenteus<\/jats:italic>\n              bacteremia among\n              <jats:italic>S. aureus<\/jats:italic>\n              bacteremia cohort in Korea.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/spectrum.02798-23","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T14:01:06Z","timestamp":1704895266000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["<i>Staphylococcus argenteus<\/i>\n            bacteremia in the Republic of Korea"],"prefix":"10.1128","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9039-8328","authenticated-orcid":false,"given":"Minkyeong","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsang","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Mi","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7132-0157","authenticated-orcid":true,"given":"Eu Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Bin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyeon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, College of Medicine, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Woo","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5332-2658","authenticated-orcid":true,"given":"Jinki","family":"Yeom","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, College of Medicine, Seoul National University, Seoul, Republic of Korea"},{"name":"Department of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1130-0506","authenticated-orcid":false,"given":"Jeong Su","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4517-3840","authenticated-orcid":true,"given":"Kyoung-Ho","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of 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