{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:26:58Z","timestamp":1790022418793,"version":"4.0.1"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2025IL0014"],"award-info":[{"award-number":["2025IL0014"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Ceftazidime\u2013avibactam (CZA) was introduced in South Korea in July 2023, but regional data on its clinical efficacy, treatment outcomes, and microbiological characteristics of bloodstream infections (BSIs) caused by\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      carbapenemase (KPC)-producing Enterobacterales remain limited. This study evaluated the effectiveness of CZA compared with conventional therapies targeting KPC-producing Enterobacterales BSIs. A retrospective observational study of adult patients with KPC-producing Enterobacterales BSIs was conducted at a tertiary care center in Seoul, Republic of Korea. Patients treated with CZA between July 2023 and November 2024 were compared with a historical cohort treated with best available agents (conventional therapy) from December 2021 to June 2023. The primary endpoint was 30-day all-cause mortality. Secondary endpoints included BSI persistence, BSI recurrence, and emergence of resistance. A total of 106 patients received CZA and 156 received best available agents. The 30-day mortality rate was significantly lower in the CZA group compared with the comparator group (15.1% vs 28.2%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02). Persistent BSI was also significantly reduced in the CZA group (5.0% vs 34.2%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). In multivariate analysis, CZA therapy was independently associated with reduced 30-day mortality (adjusted OR, 0.46; 95% CI, 0.22\u20130.92). Kaplan\u2013Meier analysis demonstrated improved survival with CZA (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.014), and CZA resistance emerged in three patients (2.8%, 3\/106). In this Korean cohort, CZA therapy was associated with significantly lower 30-day mortality and persistent BSI rates in patients with KPC-producing Enterobacterales BSIs, compared with best available agents.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        Bloodstream infections caused by\n                        <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                        carbapenemase (KPC)-producing Enterobacterales carry high mortality rates and offer few treatment options, representing an urgent public health threat. Ceftazidime\u2013avibactam (CZA) has emerged as a key therapy for these infections globally, yet real-world clinical data from South Korea have been absent since its recent introduction. This study presents the first comprehensive evaluation of CZA for treating KPC-producing Enterobacterales bloodstream infections in a Korean tertiary-care hospital. Through direct comparison with conventional combination regimens, we show that CZA substantially reduces 30-day mortality and persistent bacteremia. These findings provide important evidence for CZA as an effective first-line treatment, especially in settings where KPC-producing organisms are highly prevalent. Our results emphasize the value of timely access to novel \u03b2-lactam\/\u03b2-lactamase inhibitors and point to the ongoing need for resistance surveillance.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.02819-25","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:00:20Z","timestamp":1773320420000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of outcomes of KPC-producing Enterobacterales bloodstream infections treated with ceftazidime-avibactam and other conventional antibiotics: retrospective single-center study"],"prefix":"10.1128","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2954-3888","authenticated-orcid":false,"given":"Kyungsup","family":"Kwon","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02c2f8975","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yun","family":"Lim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02c2f8975","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine","place":["Seoul, Republic of 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Center, University of Ulsan College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-3185","authenticated-orcid":true,"given":"Yong Pil","family":"Chong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02c2f8975","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Han","family":"Kim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02c2f8975","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Ho","family":"Choi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02c2f8975","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1381-8787","authenticated-orcid":true,"given":"Sang-Oh","family":"Lee","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02c2f8975","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6785-8824","authenticated-orcid":true,"given":"Yang 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