{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:29Z","timestamp":1792787249507,"version":"4.5.0"},"reference-count":36,"publisher":"American Society for Microbiology","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","award":["Z211100002921063"],"award-info":[{"award-number":["Z211100002921063"]}],"id":[{"id":"https:\/\/ror.org\/034k14f91","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Contezolid, a novel oxazolidinone, exhibits potent activity against multidrug-resistant gram-positive pathogens, but data in pediatric populations remain limited. This study evaluated the\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      activity of contezolid against\n                      <jats:italic toggle=\"yes\">Streptococcus pneumoniae<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 53) and\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 92) isolates recovered from sterile-site specimens of pediatric patients with invasive infections (2018\u20132023). MICs were determined by broth microdilution. For\n                      <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                      , contezolid MICs ranged from 0.125 to 1.000 \u00b5g\/mL (MIC\n                      <jats:sub>50\/90<\/jats:sub>\n                      , 0.250\/0.500 \u00b5g\/mL), with comparable activity against penicillin-susceptible and penicillin-nonsusceptible isolates. Contezolid exhibited low MIC values with a relatively narrow distribution across serotypes and specimen sources, without marked differences. For\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      , contezolid MICs ranged from 0.250 to 2.000 \u00b5g\/mL (MIC\n                      <jats:sub>50\/90<\/jats:sub>\n                      , 0.500\/1.000 \u00b5g\/mL), with equivalent activity against methicillin-susceptible\n                      <jats:italic toggle=\"yes\">Staphylococcus aureu<\/jats:italic>\n                      s (MSSA) and methicillin-resistant\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      (MRSA). All isolates were susceptible, with most MICs \u2264 0.500 \u00b5g\/mL and a minority (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 25) at 1\u20132 \u00b5g\/mL, mostly involving isolates from blood. Contezolid exhibited potent and consistent\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      activity against gram-positive pathogens isolated from invasive infections in pediatric patients, including MRSA and PNSP, with stable susceptibility profiles across major clonal lineages. These findings demonstrate favorable\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      activity of contezolid against clinically significant isolates.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>\n                        <jats:bold>IMPORTANCE<\/jats:bold>\n                      <\/jats:title>\n                      <jats:p>\n                        This study provides an evaluation of the\n                        <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                        activity of contezolid against gram-positive bacterial isolates obtained exclusively from pediatric patients with invasive infections. By characterizing susceptibility patterns across resistance phenotypes and molecular backgrounds, our findings offer important baseline data to inform future clinical studies of contezolid in pediatric populations.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.02949-25","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:00:50Z","timestamp":1790168450000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["<i>In vitro<\/i>\n                    activity of contezolid against gram-positive bacteria isolated from pediatric patients with invasive infections"],"prefix":"10.1128","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1304-0269","authenticated-orcid":true,"given":"Xinrong","family":"Li","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/013xs5b60","id-type":"ROR","asserted-by":"publisher"}],"name":"Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubo","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/013xs5b60","id-type":"ROR","asserted-by":"publisher"}],"name":"Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5974-8254","authenticated-orcid":true,"given":"Suyun","family":"Qian","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/013xs5b60","id-type":"ROR","asserted-by":"publisher"}],"name":"Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/013xs5b60","id-type":"ROR","asserted-by":"publisher"}],"name":"Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt024"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12386"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2017.0147"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.148837"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05410-1"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2012.03.001"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2022.58.7.3389002"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01008-19"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01576-0"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.002105"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0326353"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-202"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00785-23"},{"key":"e_1_3_4_16_2","unstructured":"Clinical and laboratory standards institute. 2025. 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