{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:52:07Z","timestamp":1789678327338,"version":"4.0.1"},"reference-count":109,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100011033","name":"MEC | Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2016-76190-R"],"award-info":[{"award-number":["SAF2016-76190-R"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"MEC | Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019-107232RBI00"],"award-info":[{"award-number":["PID2019-107232RBI00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"\"la Caixa\" Foundation","doi-asserted-by":"publisher","award":["HR18-00267"],"award-info":[{"award-number":["HR18-00267"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"MEC | Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["BES-2017-081079"],"award-info":[{"award-number":["BES-2017-081079"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:p>\n                    The survival of malaria parasites in the changing human blood environment largely depends on their ability to alter gene expression by epigenetic mechanisms. The active state of\n                    <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n                    clonally variant genes (CVGs) is associated with euchromatin characterized by the histone mark H3K9ac, whereas the silenced state is characterized by H3K9me3-based heterochromatin.\n                  <\/jats:p>","DOI":"10.1128\/spectrum.03049-22","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T09:02:26Z","timestamp":1671008546000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Patterns of Heterochromatin Transitions Linked to Changes in the Expression of Plasmodium falciparum Clonally Variant Genes"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2098-4302","authenticated-orcid":true,"given":"Lucas","family":"Michel-Tod\u00f3","sequence":"first","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bancells","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Casas-Vila","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Rovira-Graells","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Hern\u00e1ndez-Ferrer","sequence":"additional","affiliation":[{"name":"ISGlobal, Barcelona, Catalonia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan R.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"ISGlobal, Barcelona, Catalonia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0730-6582","authenticated-orcid":true,"given":"Alfred","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Catalonia, Spain"},{"name":"ICREA, Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0306-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0000005"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2619"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1087025"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.055"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14652"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.05.018"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2011.06.004"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.020"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature23009"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00940-w"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2022.02.009"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025528"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090817-062722"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12115"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elz009"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2014.05.007"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.129692.111"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.61.080706.093134"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12183"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.47"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2006-7-2-r12"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2009.04.003"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003943"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2006.06.004"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030107"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.05.002"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.112.081224"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12162"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05767.x"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2008.08.005"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg096"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2007.07.011"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12920"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz5057"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24280"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090817-062712"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15026-0"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.07.004"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000569"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp115"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.12.012"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102444"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac176"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07574.x"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913396107"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.06009.x"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029881"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.119"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2019.04.013"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902515106"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.01.008"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001223"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-015-0029-1"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.02.075"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep40655"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04295-5"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01636-21"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005538"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix053"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2004.11.004"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2136"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2005.03.016"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165358"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0291-7"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.096"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811829106"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-026-7_14"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6042"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002964"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-6851(99)00199-1"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01097"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv730"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001083"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118865"},{"key":"e_1_3_3_77_2","doi-asserted-by":"crossref","unstructured":"Stewart LB Freville A Voss TS Baker DA Awandare GA Conway DJ. 2022. Plasmodium falciparum sexual commitment rate variation among clinical isolates and diverse laboratory-adapted lines. Microbiol Spectr doi:10.1128\/spectrum.02234-22.","DOI":"10.1128\/spectrum.02234-22"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24954-4"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1603-4"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.01093-20"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1925"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.04.018"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11174"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.16168.2"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2004328"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19988-z"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10172-6"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1086\/383250"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120455109"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104198"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260403"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06311"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-5257-x"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000644"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv207"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1086\/649902"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09982-5"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003170"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.848797"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-020-00365-5"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002943"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60058"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00325-13"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3299700"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.12-0613"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0817-x"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1681-9_10"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1214"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.07026.x"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.03.007"}],"container-title":["Microbiology Spectrum"],"original-title":[],"contributor":[{"given":"Francesca","family":"Florini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-6749","authenticated-orcid":false,"given":"Jun","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]}],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.03049-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.03049-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T09:36:12Z","timestamp":1676367372000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.03049-22"}},"subtitle":[],"editor":[{"given":"Laura A.","family":"Kirkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":109,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2,14]]}},"alternative-id":["10.1128\/spectrum.03049-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.03049-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,14]]},"assertion":[{"value":"2022-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03049-22"}}