{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:50:46Z","timestamp":1786117846304,"version":"build-2736575974"},"reference-count":146,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31672532"],"award-info":[{"award-number":["31672532"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SIPT Project of Northeast Agricultural University"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      is a major global health threat due to its increasing antibiotic resistance and high virulence, presenting serious challenges in healthcare. Currently, no effective vaccine exists to prevent its infections. In our study, we introduced a novel multi-epitope vaccine design method using immunoinformatics, named the \u201cJust the Best Ones\u201d strategy. This approach involved selecting the most promising T-cell and B-cell epitopes from 10 key proteins of\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      based on the pathogenic mechanism of the bacterium in the host, to create the\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      Multi-Epitope Antigen (SAMEA) with optimal immunogenicity. Physicochemical and structural analyses confirmed SAMEA\u2019s stability and suitable profiles for antigenicity, toxicity, and allergenicity. Molecular docking showed strong interactions between SAMEA and human TLR2, crucial for eliciting effective immune responses. Additionally, SAMEA was highly immunogenic and safe, generating a strong antibody response and excellent protection in mice. These results suggest that SAMEA is a promising multi-epitope vaccine candidate, highlighting the \u201cJust the Best Ones\u201d strategy\u2019s effectiveness, and introducing a new direction in vaccine development against\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>\n                      Methicillin-resistant\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      (MRSA) is a major health threat due to its antibiotic resistance and ability to cause severe infections in humans and animals. Yet, no licensed vaccine is available. Here, we present a \u201cJust the Best Ones\u201d strategy that applies immunoinformatics to select the most protective epitopes from key\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      antigens. Using this approach, we developed a multi-epitope antigen (SAMEA) that proved safe, highly immunogenic, and protective in mice, particularly when combined with a bacterium-like particle adjuvant. These results highlight SAMEA as a promising MRSA vaccine candidate and indicate that this strategy may help guide vaccine development for other difficult pathogens. As it continues to be refined, this approach could facilitate more effective vaccines and improve the prevention of infectious diseases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.03085-25","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:08:45Z","timestamp":1783948125000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["\u201cJust the Best Ones\u201d combination: a new strategy for multi-epitope vaccine candidate based on immunoinformatics analysis to induce protective immunity against MRSA infection"],"prefix":"10.1128","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8370-230X","authenticated-orcid":false,"given":"Qingru","family":"Chang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of 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