{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:15:21Z","timestamp":1788225321682,"version":"build-2803163510"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["HHSN272201600029C"],"award-info":[{"award-number":["HHSN272201600029C"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5R44AI109879-04A1"],"award-info":[{"award-number":["5R44AI109879-04A1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI111539"],"award-info":[{"award-number":["R01AI111539"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01BX001974"],"award-info":[{"award-number":["1I01BX001974"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01BX002872"],"award-info":[{"award-number":["1I01BX002872"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Ledaborbactam is a novel boronic-acid inhibitor of class A, C, and D \u03b2-lactamases, including OXA-48, being developed in combination with ceftibuten. Herein, we examined the\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      activity of this combination vs. other orally bioavailable compounds against 50 Enterobacterales-carrying\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>OXA-48<\/jats:sub>\n                      . Ranked by MIC\n                      <jats:sub>90<\/jats:sub>\n                      , ceftibuten-ledaborbactam was the most active (0.5 mg\/L), followed by levofloxacin and tebipenem (8 mg\/L), sulopenem (16 mg\/L), and ceftibuten-clavulanic acid, ceftibuten and amoxicillin-clavulanic acid (\u226532 mg\/L).\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        Carbapenemase-producing Enterobacterales (CPE) that produce class D OXA-48-like carbapenemases are among the most challenging pathogens to treat. Therefore, new compounds with\n                        <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                        activity against these bacteria are crucial due to the limited options available. In this study, we compared the\n                        <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                        antimicrobial activity of ceftibuten-ledaborbactam with that of other oral antibiotics, including tebipenem, sulopenem, ceftibuten-clavulanic acid, amoxicillin-clavulanic acid, and levofloxacin, against OXA-48-producing Enterobacterales. Our results show that ceftibuten-ledaborbactam has the most potent activity, with an MIC\n                        <jats:sub>90<\/jats:sub>\n                        of 0.5 mg\/L.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.03148-25","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T14:10:47Z","timestamp":1766499047000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the activity of a novel orally bioavailable \u03b2-lactam-\u03b2-lactamase inhibitor combination, ceftibuten-ledaborbactam, against Enterobacterales-carrying\n                    <i>bla<\/i>\n                    <sub>OXA-48<\/sub>"],"prefix":"10.1128","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-9824","authenticated-orcid":true,"given":"Maria F.","family":"Mojica","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Biology and Microbiology, Case Western Reserve University","place":["Cleveland, USA"]},{"name":"Research Service, Veterans Affairs Northeast Ohio Healthcare System","place":["Cleveland, USA"]},{"name":"CASE-VA Center for Antimicrobial Resistance and Epidemiology","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise T.","family":"Zeiser","sequence":"additional","affiliation":[{"name":"Research Service, Veterans Affairs Northeast Ohio Healthcare System","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Becka","sequence":"additional","affiliation":[{"name":"Research Service, Veterans Affairs Northeast Ohio Healthcare System","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9013-1711","authenticated-orcid":false,"given":"David A.","family":"Six","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02s3j1d69","id-type":"ROR","asserted-by":"publisher"}],"name":"Venatorx Pharmaceuticals Inc.","place":["Malvern, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-7227","authenticated-orcid":true,"given":"Greg","family":"Moeck","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02s3j1d69","id-type":"ROR","asserted-by":"publisher"}],"name":"Venatorx Pharmaceuticals Inc.","place":["Malvern, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3299-894X","authenticated-orcid":true,"given":"Robert A.","family":"Bonomo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Biology and Microbiology, Case Western Reserve University","place":["Cleveland, USA"]},{"name":"CASE-VA Center for Antimicrobial Resistance and Epidemiology","place":["Cleveland, USA"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicine, Case Western Reserve University","place":["Cleveland, USA"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, Case Western Reserve University","place":["Cleveland, USA"]},{"id":[{"id":"https:\/\/ror.org\/01vrybr67","id-type":"ROR","asserted-by":"publisher"}],"name":"Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland VA Medical Center","place":["Cleveland, USA"]},{"id":[{"id":"https:\/\/ror.org\/02x4b0932","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, Case Western Reserve University School of Medicine","place":["Cleveland, USA"]},{"id":[{"id":"https:\/\/ror.org\/02x4b0932","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Proteomics and Bioinformatics, Case Western Reserve University School of Medicine","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-7898","authenticated-orcid":false,"given":"Krisztina M.","family":"Papp-Wallace","sequence":"additional","affiliation":[{"name":"Research Service, Veterans Affairs Northeast Ohio Healthcare System","place":["Cleveland, USA"]},{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicine, Case Western Reserve University","place":["Cleveland, 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Performance Standards for Antimicrobial Susceptiblity Testing. In CLSI supplement M100. Clinical and Laboratory Standards Institute, USA."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki074"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.03148-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.03148-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:47:47Z","timestamp":1788223667000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.03148-25"}},"subtitle":[],"editor":[{"given":"Gabriele","family":"Arcari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,3]]}},"alternative-id":["10.1128\/spectrum.03148-25"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.03148-25","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,3]]},"assertion":[{"value":"2025-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03148-25"}}