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Bacteria maintain zinc homeostasis through regulators, such as Zur, AdcR, and ZntR.\n                      <jats:italic>Riemerella anatipestifer<\/jats:italic>\n                      is a significant\n                      <jats:italic>Flavobacteriales<\/jats:italic>\n                      pathogen causing acute serositis in ducks and other birds. In this study, we identified a homolog of ZntR, a regulator for zinc homeostasis, and demonstrated its contribution to the pathogenicity of\n                      <jats:italic>R. anatipestifer<\/jats:italic>\n                      . Deletion of\n                      <jats:italic>zntR<\/jats:italic>\n                      makes the bacteria hypersensitive to excess Zn\n                      <jats:sup>2+<\/jats:sup>\n                      but not to other metals like manganese (Mn\n                      <jats:sup>2+<\/jats:sup>\n                      ), copper (Cu\n                      <jats:sup>2+<\/jats:sup>\n                      ), cobalt (Co\n                      <jats:sup>2+<\/jats:sup>\n                      ), and nickel (Ni\n                      <jats:sup>2+<\/jats:sup>\n                      ). Deletion of\n                      <jats:italic>zntR<\/jats:italic>\n                      also leads to intracellular zinc accumulation but not of other metals. Additionally, compared to the wild type, the deletion of\n                      <jats:italic>zntR<\/jats:italic>\n                      increases resistance to oxidants hydrogen peroxide (H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      ) and sodium hypochlorite (NaOCl), respectively. The deletion of\n                      <jats:italic>zntR<\/jats:italic>\n                      causes significant changes in transcriptional and protein expression levels, revealing 35 genes with potential zinc metabolism functions. Among them,\n                      <jats:italic>zupT<\/jats:italic>\n                      , which is inhibited by ZntR, is required for zinc transport and resistance to oxidative stress. Finally, deletion of\n                      <jats:italic>zntR<\/jats:italic>\n                      leads to attenuation of colonization in ducklings. In summary, ZntR is a crucial regulator for zinc homeostasis and contributes to the pathogenicity of\n                      <jats:italic>R. anatipestifer<\/jats:italic>\n                      .\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        Zinc homeostasis plays a critical role in the environmental adaptability of bacteria.\n                        <jats:italic>Riemerella anatipestifer<\/jats:italic>\n                        is a significant pathogen in poultry with the potential to encounter zinc-deficient or zinc-excess environment. The mechanism of zinc homeostasis in this bacterium remains largely unexplored. In this study, we showed that the transcriptional regulator ZntR of\n                        <jats:italic>R. anatipestifer<\/jats:italic>\n                        is critical for zinc homeostasis by altering the transcription and expression of a number of genes. Importantly, ZntR inhibits the transcription of zinc transporter ZupT and contributes to colonization in\n                        <jats:italic>R. anatipestifer<\/jats:italic>\n                        . The results are significant for understanding zinc homeostasis and the pathogenic mechanisms in\n                        <jats:italic>R. anatipestifer<\/jats:italic>\n                        .\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.03178-24","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T09:03:17Z","timestamp":1741078997000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["ZntR is a critical regulator for zinc homeostasis and involved in pathogenicity in\n                    <i>Riemerella anatipestifer<\/i>"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9579-3440","authenticated-orcid":false,"given":"Hongmeng","family":"Ma","sequence":"first","affiliation":[{"name":"Engineering Research Center of Southwest Animal Disease Prevention and Control 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