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This study revealed that orally administered hypoactive\n                      <jats:italic toggle=\"yes\">Akkermansia muciniphila<\/jats:italic>\n                      inhibited dopaminergic neuron loss in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model. Its ingestion also reduced astrocyte activation and mitigated inflammatory responses in both the brain and colon. Additionally, hypoactive\n                      <jats:italic toggle=\"yes\">Akkermansia muciniphila<\/jats:italic>\n                      modulated intestinal microbiota composition in PD model mice. These findings suggest that hypoactive\n                      <jats:italic toggle=\"yes\">Akkermansia muciniphila<\/jats:italic>\n                      reduces neurotoxicity in an MPTP-induced PD model and may offer potential for inhibiting PD progression.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        Recent research suggests a connection between Parkinson\u2019s disease (PD) and the microbiota-gut-brain axis, with evidence indicating that probiotics may alleviate PD symptoms. Although\n                        <jats:italic toggle=\"yes\">Akkermansia muciniphila<\/jats:italic>\n                        has demonstrated potential benefits for certain neurological disorders, its efficacy in the treatment of PD is still a subject of ongoing debate. Here, we demonstrated that hypoactive\n                        <jats:italic toggle=\"yes\">Akkermansia muciniphila<\/jats:italic>\n                        ameliorated dopaminergic neuronal death, correlating to the reduction of glial hyperactivation and neuroinflammation. Hypoactive\n                        <jats:italic toggle=\"yes\">Akkermansia muciniphila<\/jats:italic>\n                        also induced microbiota fluctuation, which may perform a sophisticated effect on PD progression. Our study may provide an innovative strategy for using hypoactive\n                        <jats:italic toggle=\"yes\">Akkermansia muciniphila<\/jats:italic>\n                        as a therapy or adjuvant therapy for PD.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.03379-24","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T17:09:56Z","timestamp":1762967396000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Neuroprotective effects of hypoactive\n                    <i>Akkermansia muciniphila<\/i>\n                    in MPTP-induced mouse models of Parkinson\u2019s disease"],"prefix":"10.1128","volume":"13","author":[{"given":"Jiahui","family":"Xi","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China 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