{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:33:29Z","timestamp":1787016809901,"version":"build-2736575974"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372292"],"award-info":[{"award-number":["82372292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2025,12,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      To understand the prevalence and phylogeny of methicillin-resistant\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      (MRSA) in Chinese hospitals and\n                        identify the dominant MRSA lineages causing hospital infections, we\n                        collected 101\n                      <jats:italic toggle=\"yes\">S<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">aureus<\/jats:italic>\n                      isolates from\n                        multiple centers across China, tested their antibiotic sensitivity, and\n                        performed whole-genome sequencing. Using our group\u2019s database, a core\n                        genome-based phylogenetic analysis of 204\n                      <jats:italic toggle=\"yes\">S<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">aureus<\/jats:italic>\n                      isolates was conducted. The results revealed an\n                        interspersed distribution of MRSA and MSSA without distinct clade\n                        separation. CC59-ST59-t437-SCC\n                      <jats:italic toggle=\"yes\">mec<\/jats:italic>\n                      IV was identified as the\n                        predominant community-associated MRSA (CA-MRSA) clone widely distributed\n                        across cities, while hospital-associated MRSA (HA-MRSA) was mainly composed\n                        of CC5-ST5-SCC\n                      <jats:italic toggle=\"yes\">mec<\/jats:italic>\n                      II and CC8-ST239-SCC\n                      <jats:italic toggle=\"yes\">mec<\/jats:italic>\n                      III, forming significant phylogenetic clusters. In contrast, MSSA strains\n                        were more diverse, with no clear clustering patterns. No regional clustering\n                        was observed, suggesting a widespread dissemination of major clones\n                        nationwide. Notably, some sequence types (e.g., ST45 and ST59) were shared\n                        by both MRSA and MSSA, and closely related strains with and without\n                            SCC\n                      <jats:italic toggle=\"yes\">mec<\/jats:italic>\n                      elements suggested that smaller\n                            SCC\n                      <jats:italic toggle=\"yes\">mec<\/jats:italic>\n                      types may be more readily gained or lost during\n                        evolution. Our findings indicate that CA-MRSA has a significant presence in\n                        hospitals with diverse subtypes, highlighting the need for increased\n                        attention to CA-MRSA in S.\n                      <jats:italic toggle=\"yes\">aureus<\/jats:italic>\n                      control and\n                        prevention.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        The aim of this study was to identify the molecular epidemiological\n                            characteristics of\n                        <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                        in Chinese hospitals,\n                            especially the dominant typing changes of MRSA during transmission. This\n                            study found that CA-MRSA appeared in the hospital environment with high\n                            diversity, suggesting that clinical attention should be paid to CA-MRSA\n                            in the prevention and diagnosis of\n                        <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                        infection.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.03395-24","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:04:22Z","timestamp":1761829462000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Unveiling the emergence of community-acquired methicillin-resistant\n                    <i>Staphylococcus aureus<\/i>\n                    (CA-MRSA) in Chinese hospitals with                    remarkable genetic diversity: a multicenter molecular epidemiological                    investigation"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0706-6007","authenticated-orcid":false,"given":"Shangyu","family":"Tu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/035adwg89","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Laboratory, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/035adwg89","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Laboratory, Peking University People\u2019s Hospital","place":["Beijing, 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