{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T09:29:16Z","timestamp":1780824556586,"version":"3.54.1"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/AuthorWarrantyLicense.v1"},{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2023,6,15]]},"abstract":"<jats:p>Severe liver impairment is a well-known hallmark of Ebola virus disease (EVD), but the contribution of hepatic pathophysiology to EVD progression is not fully understood. Noninvasive medical imaging of liver structure and function in well-established animal models of disease may shed light on this important aspect of EVD.<\/jats:p>","DOI":"10.1128\/spectrum.03538-22","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T14:33:10Z","timestamp":1684161190000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Magnetic Resonance Imaging for Monitoring of Hepatic Disease Induced by Ebola Virus: a Nonhuman Primate Proof-of-Concept Study"],"prefix":"10.1128","volume":"11","author":[{"given":"Ji Hyun","family":"Lee","sequence":"first","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-8728","authenticated-orcid":false,"given":"Claudia","family":"Calcagno","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin M.","family":"Feuerstein","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Solomon","sequence":"additional","affiliation":[{"name":"Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-2918","authenticated-orcid":true,"given":"Venkatesh","family":"Mani","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Huzella","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3450-0989","authenticated-orcid":false,"given":"Marcelo A.","family":"Castro","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Laux","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Reeder","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Yun","family":"Kim","sequence":"additional","affiliation":[{"name":"Office of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Worwa","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Thomasson","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie R.","family":"Hagen","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny R.","family":"Ragland","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-6045","authenticated-orcid":false,"given":"Jens H.","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-0550","authenticated-orcid":true,"given":"Reed F.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"},{"name":"Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","unstructured":"National Institute of Allergy and Infectious Diseases. 2018. NIAID emerging infectious diseases\/pathogens. https:\/\/www.niaid.nih.gov\/research\/emerging-infectious-diseases-pathogens. Accessed 14 March 2023."},{"key":"e_1_3_3_3_2","unstructured":"Centers for Diseases Control and Prevention National Institutes of Health. 2009. Biosafety in microbiological and biomedical laboratories 5th ed. https:\/\/www.cdc.gov\/labs\/pdf\/CDC-BiosafetyMicrobiologicalBiomedicalLaboratories-2009-P.PDF. Accessed 14 March 2023."},{"key":"e_1_3_3_4_2","unstructured":"World Health Organization. 2016. Ebola virus disease: situation report 10 June 2016. https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/208883\/ebolasitrep_10Jun2016_eng.pdf;jsessionid=10D2AB24D49F9C07E139A2C8D0CBCE02?sequence=1. Accessed 14 March 2023."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/514319"},{"key":"e_1_3_3_6_2","first-page":"97","article-title":"Pathologic features of filovirus infections in humans","volume":"235","author":"Zaki SR","year":"1999","unstructured":"Zaki SR, Goldsmith CS. 1999. Pathologic features of filovirus infections in humans. Curr Top Microbiol Immunol 235:97\u2013116.","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_3_7_2","first-page":"43","volume-title":"Ebola virus haemorrhagic fever.","author":"Murphy FA","year":"1978","unstructured":"Murphy FA. 1978. Pathology of Ebola virus infection, p 43\u201359. In Pattyn SR (ed), Ebola virus haemorrhagic fever. Elsevier\/North-Holland Biomedical Press, Amsterdam, Netherlands."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix562"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3691-z"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1815356116"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0147-3"},{"key":"e_1_3_3_12_2","first-page":"253","article-title":"Animal models of ebolavirus infection","volume":"67","author":"St Claire MC","year":"2017","unstructured":"St Claire MC, Ragland DR, Bollinger L, Jahrling PB. 2017. Animal models of ebolavirus infection. Comp Med 67:253\u2013262.","journal-title":"Comp Med"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1213709109"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63591-2"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14442"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.67"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15012-X"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000343092"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.171.2.2704798"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0b013e3181c42454"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014784"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i5.622"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2018.08.008"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-020-02779-x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/v6114666"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.08.008"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199807000-00026"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2014.0085"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17180"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199207000-00012"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365548809032449"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.183.1.1549695"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.113.055707"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw267"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780021"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12171"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/v4123511"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-014-3024-y"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-017-0558-1"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.11.014"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3873-2"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-016-0685-z"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2010.03.008"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1179\/oeh.2006.12.4.369"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23691"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23088-x"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.11.004"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.03538-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.03538-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T19:19:47Z","timestamp":1723403987000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.03538-22"}},"subtitle":[],"editor":[{"given":"Chad J.","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,6,15]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6,15]]}},"alternative-id":["10.1128\/spectrum.03538-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.03538-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,15]]},"assertion":[{"value":"2022-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03538-22"}}