{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:42:11Z","timestamp":1761716531354,"version":"3.41.2"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Special funds for the central government to guide local science and technology development","award":["ZYYD2022A06"],"award-info":[{"award-number":["ZYYD2022A06"]}]},{"name":"Autonomous region science and technology frontier project plan","award":["2022E02041"],"award-info":[{"award-number":["2022E02041"]}]},{"name":"Hospital project of People's Hospital of Xinjiang Uygur Autonomous Region","award":["20230107"],"award-info":[{"award-number":["20230107"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n There has been a suggestion of a potential protective effect of\n Helicobacter pylori<\/jats:italic>\n (\n H. pylori<\/jats:italic>\n ) in the development of ulcerative colitis (UC). Virulence factor is an important factor in\n H. pylori<\/jats:italic>\n , but little is known about the clinical characteristics of ulcerative colitis. In this retrospective study, a total of 322 patients with UC were analyzed. They were divided into three groups based on\n H. pylori<\/jats:italic>\n antibody typing classification: type I\n H. pylori<\/jats:italic>\n infection group, type II\n H. pylori<\/jats:italic>\n infection group, and\n H. pylori<\/jats:italic>\n -negative group. The study aimed to analyze the clinical characteristics of different types of\n H. pylori<\/jats:italic>\n infection groups. The proportions of disease course, nationality, clinical type, and disease severity among UC patients in different types of\n H. pylori<\/jats:italic>\n infection groups exhibited statistically significant differences (\n P<\/jats:italic>\n < 0.05). However, no significant differences were observed in terms of sex, age, smoking status, alcohol consumption, body mass index (BMI), or lesion range (\n P<\/jats:italic>\n > 0.05). Among the extraintestinal manifestations, the incidence of joint lesions in the type I\n H. pylori<\/jats:italic>\n infection group was significantly lower compared with\n H. pylori<\/jats:italic>\n -negative group (\n P<\/jats:italic>\n < 0.05). The levels of red blood cell, hemoglobin, packed cell volume, albumin, A\/G, and alanine aminotransferase were significantly higher in the type I\n H. pylori<\/jats:italic>\n infection group compared with both the type II\n H. pylori<\/jats:italic>\n infection group and\n H. pylori<\/jats:italic>\n -negative group in the hematology index. Conversely, the levels of D-Dimer, C-reactive protein, and erythrocyte sedimentation rate were significantly lower in the type II\n H. pylori<\/jats:italic>\n infection group (\n P<\/jats:italic>\n < 0.05). In patients with UC, infections with the highly virulent type I\n H. pylori<\/jats:italic>\n exhibit a negative correlation with both the severity of the disease and extraintestinal manifestations. While infections with the less virulent type II\n H. pylori<\/jats:italic>\n are negatively correlated only with the disease severity. Therefore, the virulence factors of\n H. pylori<\/jats:italic>\n play an important role in the regulation of UC.\n <\/jats:p>\n <\/jats:sec>\n \n IMPORTANCE<\/jats:title>\n \n The number of patients with ulcerative colitis (UC) has increased dramatically worldwide, posing a global public health challenge, There has been a suggestion of a potential protective effect of\n Helicobacter pylori<\/jats:italic>\n in the development of UC. Virulence factor is an important factor in\n H. pylori<\/jats:italic>\n , but high-quality clinical evidence is lacking. This study comprehensively analyzed the clinical characteristics of UC patients with different types of\n H. pylori<\/jats:italic>\n infection. Infections with the highly virulent type I\n H. pylori<\/jats:italic>\n are found to be negatively correlated with the severity of the disease as well as extraintestinal manifestations, whereas infections with the less virulent type II\n H. pylori<\/jats:italic>\n demonstrate a negative correlation solely with disease severity. These results suggest that the virulence factors of\n H. pylori<\/jats:italic>\n play a pivotal role in UC. Consequently, virulence factors should be taken into consideration when targeting\n H. pylori<\/jats:italic>\n eradication in clinical practice, particularly in UC patients. It is crucial to evaluate the individual benefits to optimize personalized eradication therapies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1128\/spectrum.03554-23","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T13:00:20Z","timestamp":1713186020000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Clinical characteristics of ulcerative colitis patients with different types of\n Helicobacter pylori<\/i>\n infection"],"prefix":"10.1128","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3320-3958","authenticated-orcid":true,"given":"Weidong","family":"Liu","sequence":"first","affiliation":[{"name":"College of Life Science and Technology, Xinjiang University, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"},{"name":"Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglong","family":"Xue","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Xinjiang University, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6055-1339","authenticated-orcid":true,"given":"Wenjia","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"},{"name":"Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"},{"name":"Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"},{"name":"Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3320-5702","authenticated-orcid":true,"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China"},{"name":"Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29649-y"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154052"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.37345"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac202"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.972777"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i1.91"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010027"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.999564"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12994"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz149"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32126-2"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.04.016"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001415"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.34172\/aim.2021.44"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S353329"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.2101.01023"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16051"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy107"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107012"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep10024"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-022-00486-0"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02571-9"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327745"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002546"}],"container-title":["Microbiology 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