{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:23:34Z","timestamp":1789431814726,"version":"build-2803163510"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"MOST | National Key Research and Development Program of China","award":["2022YFC2303002"],"award-info":[{"award-number":["2022YFC2303002"]}]},{"name":"Tsinghua university peking union medical college hospital initiative scientific research program","award":["20191080604"],"award-info":[{"award-number":["20191080604"]}]},{"name":"National science and technology basic resource investigation special program of China","award":["2019FY101200"],"award-info":[{"award-number":["2019FY101200"]}]},{"DOI":"10.13039\/501100005090","name":"BMSTC | Beijing Nova Program","doi-asserted-by":"publisher","award":["Z201100006820127"],"award-info":[{"award-number":["Z201100006820127"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"MOST | National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1603800"],"award-info":[{"award-number":["2018YFC1603800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:p>\n            Invasive candidiasis is the most common human fungal disease among hospitalized patients, and\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            is the predominant pathogen. Considering the large number of infected cases and the limited alternative therapies, the azole-resistance of\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            brings a huge clinical threat.\n          <\/jats:p>","DOI":"10.1128\/spectrum.03807-22","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T14:01:46Z","timestamp":1674741706000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Emergence of Antifungal Resistant Subclades in the Global Predominant Phylogenetic Population of Candida albicans"],"prefix":"10.1128","volume":"11","author":[{"given":"Jie","family":"Gong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Sate Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6257-5115","authenticated-orcid":true,"given":"Xin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Sate Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Beijing University First Hospital, Beijing, China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China"},{"name":"Research Center for Medical Mycology, Beijing University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon C-A","family":"Chen","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanrong","family":"Kong","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Yong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Wen","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Beijing University First Hospital, Beijing, China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Dong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Tianjin Medical University General Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Zhuo","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First Hospital of China Medical University, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Mei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The People's Hospital of Liaoning Province, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Ling","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Shen","sequence":"additional","affiliation":[{"name":"Center for Statistical Science, and Department of Industrial Engineering, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Geng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, the Fifth People's Hospital of Hainan Province, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[{"name":"Dynamiker Sub-center of Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Disease, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hua","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Agro-Biotechnology Research Center, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Sate Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-1935","authenticated-orcid":true,"given":"Jian-Zhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2103-7008","authenticated-orcid":true,"given":"Meng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Sate Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1315399"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.26"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0322-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.02173"},{"key":"e_1_3_3_7_2","volume-title":"Status report on monitoring capacity and management of mycosis in chinese medical institutions (2020)","author":"China Fungal Disease Surveillance System","year":"2022","unstructured":"China Fungal Disease Surveillance System. Status report on monitoring capacity and management of mycosis in chinese medical institutions (2020). 2022. Beijing: Peking Union Medical College Press."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00662"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30316-X"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/1567-1364.12042"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12027"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/fox012"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03470-14"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00303-10"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2013.11.008"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00041-07"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04787-4"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.09.113"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myu003"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.11.007"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.2223-2227.2004"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/35072023"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3322"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1595"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03364-19"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2009.00577.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.11.2985-2990.2000"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyab029"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00365-20"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2021.1934557"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-015-1146-8"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00069-09"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz537"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myv002"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01130-12"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myv008"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02543-13"},{"key":"e_1_3_3_38_2","volume-title":"CLSI.","author":"Anonymous","year":"2017","unstructured":"Anonymous. 2017. CLSI. M27, 4th edition Clinical and Laboratory Standards Institute.","edition":"27"},{"key":"e_1_3_3_39_2","volume-title":"CLSI.","author":"Anonymous","year":"2017","unstructured":"Anonymous. 2017. CLSI. M60, 1st edition Clinical and Laboratory Standards Institute.","edition":"60"},{"key":"e_1_3_3_40_2","volume-title":"CLSI.","author":"Anonymous","year":"2018","unstructured":"Anonymous. 2018. CLSI. M59, 2nd edition Clinical and Laboratory Standards Institute.","edition":"59"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp698"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_3_44_2","volume-title":"GATK, and WDL in Terra","author":"Van der Auwera GA","year":"2020","unstructured":"Van der Auwera GA, O'Connor BD. 2020. Genomics in the cloud: using docker, GATK, and WDL in Terra (1st Edition). O'Reilly Media.","edition":"1"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msu300"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.094052.109"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42770-018-0009-2"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.10.2693-2700.2000"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.03807-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.03807-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:59:58Z","timestamp":1676386798000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.03807-22"}},"subtitle":[],"editor":[{"given":"Teresa R.","family":"O\u2019Meara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2,14]]}},"alternative-id":["10.1128\/spectrum.03807-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.03807-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,14]]},"assertion":[{"value":"2022-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03807-22"}}