{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:55:25Z","timestamp":1753883725954,"version":"3.41.2"},"reference-count":60,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI150961"],"award-info":[{"award-number":["R01AI150961"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI142380"],"award-info":[{"award-number":["R21AI142380"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005302","name":"UofI | University of Illinois at Urbana-Champaign","doi-asserted-by":"publisher","award":["Start-up funds"],"award-info":[{"award-number":["Start-up funds"]}],"id":[{"id":"10.13039\/100005302","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:p>\n            The intestinal parasite\n            <jats:named-content content-type=\"genus-species\">Cryptosporidium parvum<\/jats:named-content>\n            is a major cause of diarrhea-associated morbidity and mortality in children, immunocompromised people, and young ruminant animals. With no effective drug available to treat cryptosporidiosis in humans and animals, there is an urgent need to identify anti-parasitic compounds and new targets for drug development.\n          <\/jats:p>","DOI":"10.1128\/spectrum.03874-22","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T14:01:38Z","timestamp":1671458498000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Tyrosine Kinase Inhibitors Display Potent Activity against Cryptosporidium parvum"],"prefix":"10.1128","volume":"11","author":[{"given":"Maria G.","family":"Nava","sequence":"first","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Global Health, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Global Health, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lluis","family":"Ballell","sequence":"additional","affiliation":[{"name":"Global Health, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Bamborough","sequence":"additional","affiliation":[{"name":"Molecular Design, GlaxoSmithKline, Stevenage, Herts, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4549-6268","authenticated-orcid":true,"given":"Sumiti","family":"Vinayak","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60844-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30076-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu653"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30362-1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30283-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2018.08.018"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001503"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2019.11.005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6825a3"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009057"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-195"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11401-2"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2020.09.010"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22337"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2020.1812577"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09880-w"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00052-20"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.7b00247"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005373"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aba8412"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814685116"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02061-18"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2017.08.006"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02460-12"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix689"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.1c00076"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006673"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1810137115"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.11.92"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.1c00387"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00724"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3374"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0242372"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14651"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix120"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01278-20"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/md20040240"},{"key":"e_1_3_3_39_2","unstructured":"Ledeboer MW Wannamaker MW Farmer LJ Wang T Pierce AC Martinez-Botella G Bethiel RS Wang J Salituro FG Arnost MJ Come JH Green J Stewart M Marhefka C. 2006. Pyrrolopyridines useful as inhibitors of protein kinase. WO2006127587."},{"key":"e_1_3_3_40_2","unstructured":"Harris P Jung D Peel MR Reno M Rheault TR Stanford J Stevens KL Veal JM. 2003. Pyrazoloparidazine derivatives. WO03\/051886 A1."},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.04.029"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm8011036"},{"key":"e_1_3_3_43_2","unstructured":"Angell RM Baldwin IR Cockerill SG Good A Skone PA. 2002. Quinoline derivative as tyrosine kinase inhibitor. WO 02\/068394 A1."},{"key":"e_1_3_3_44_2","first-page":"85","article-title":"The effects of the novel, reversible epidermal growth factor receptor\/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo","volume":"1","author":"Rusnak DW","year":"2001","unstructured":"Rusnak DW, Lackey K, Affleck K, Wood ER, Alligood KJ, Rhodes N, Keith BR, Murray DM, Knight WB, Mullin RJ, Gilmer TM. 2001. The effects of the novel, reversible epidermal growth factor receptor\/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther 1:85\u201394.","journal-title":"Mol Cancer Ther"},{"key":"e_1_3_3_45_2","unstructured":"Adjabeng G Bifulco N Davis-Ward R Dickerson SH Hornberger K Petrov K Rheault TR Uehling DE Waterson AG. 2009. Thiazole and oxazole kinase inhibitors. WO 2009\/076140 A1."},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.06.084"},{"key":"e_1_3_3_47_2","unstructured":"Bilodeau MT Rodman L. 2005. Tyrosine kinase inhibitors. US 2005\/0228031 A1."},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.8b00136"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-478"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2020.11.006"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00301-18"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0434-3"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.5b00136"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01691-13"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-6-127"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix247"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.2.844-852.1999"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401592200"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01231-20"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1068"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-016-1433-7"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.03874-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.03874-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:45:56Z","timestamp":1676385956000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.03874-22"}},"subtitle":[],"editor":[{"given":"Bj\u00f6rn F.C.","family":"Kafsack","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2,14]]}},"alternative-id":["10.1128\/spectrum.03874-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.03874-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"type":"electronic","value":"2165-0497"}],"subject":[],"published":{"date-parts":[[2023,2,14]]},"assertion":[{"value":"2022-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03874-22"}}