{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:35:21Z","timestamp":1787016921486,"version":"build-2736575974"},"reference-count":69,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100008893","name":"University of Iowa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008893","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2023,4,13]]},"abstract":"<jats:p>Toxic shock syndrome toxin 1 (TSST-1) and staphylococcal enterotoxins B and C cause the majority of cases of staphylococcal toxic shock syndrome. Previously, vaccine toxoids of TSST-1 have been prepared. In this study, vaccine toxoids of enterotoxins B and C were prepared. The toxoids lost biological toxicity but were able to vaccinate rabbits against lethal TSS.<\/jats:p>","DOI":"10.1128\/spectrum.04446-22","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T09:01:56Z","timestamp":1677142916000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Staphylococcal Enterotoxin B and C Mutants and Vaccine Toxoids"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8314-9369","authenticated-orcid":true,"given":"Patrick M.","family":"Schlievert","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00104-12"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.55.1.77"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00032-19"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.257.8.1053"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/164.6.1245"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.58.7.2067-2070.1990"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00214-19"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00803-20"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.03.004"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.3.1385"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.6.823"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.16.2.673-679.1977"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.36.1.123-128.1982"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.22.3.681-688.1978"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408419009105728"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.11.7169-7172.2001"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/151.1.65"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.1.371-374.1996"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.152.1.87"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2017.1268921"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit823"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.067"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.9.5011-5017.2000"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.4.2306"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/143.4.509"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540250046030"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00608-21"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.08.438"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.196-203.2003"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.6.3630-3634.2000"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12100640"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0969-2126(02)00759-1"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0969-2126(03)00187-4"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/384188a0"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.6.1833"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(01)00092-9"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(00)80646-9"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560060610"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.9.9.1847"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911032107"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002390010116"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00741-07"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi962614f"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi990721e"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi9721896"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.9.4628-4634.2005"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00228-08"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/148.4.692"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/147.3.391"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.2.387"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/346471a0"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.137.11.3572"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00333979"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.52.1.144-150.1986"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.131.3.611"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3308"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1256-1264.2001"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00071-16"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199808000-00015"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.8.593"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1086\/428573"},{"key":"e_1_3_2_63_2","volume-title":"Guns, germs, and steel. The fates of human societies.","author":"Diamond J","year":"1997","unstructured":"Diamond J. 1997. Guns, germs, and steel. The fates of human societies. WW Norton and Company, New York, NY."},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.5.1994"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00436"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041157"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.2.428-432.1987"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00260504"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(88)65009-9"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02554-14"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.04446-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.04446-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T09:57:43Z","timestamp":1681379863000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.04446-22"}},"subtitle":[],"editor":[{"given":"Ana-Maria","family":"Dragoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,4,13]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4,13]]}},"alternative-id":["10.1128\/spectrum.04446-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.04446-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,13]]},"assertion":[{"value":"2022-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e04446-22"}}