{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:38:12Z","timestamp":1792197492851,"version":"4.4.0"},"reference-count":71,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Senior User Project of RV KEXUE","award":["KEXUE2019GZ05"],"award-info":[{"award-number":["KEXUE2019GZ05"]}]},{"name":"CAMS Innovation Fund for Medical Science","award":["2021-I2M-1-022"],"award-info":[{"award-number":["2021-I2M-1-022"]}]},{"DOI":"10.13039\/501100012166","name":"MOST | National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0905500"],"award-info":[{"award-number":["2019YFA0905500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"MOST | National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2301000"],"award-info":[{"award-number":["2021YFC2301000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970553"],"award-info":[{"award-number":["31970553"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52091541"],"award-info":[{"award-number":["52091541"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571288"],"award-info":[{"award-number":["31571288"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2023,4,13]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            is an opportunistic pathogen that causes invasive infections with a high mortality rate. Currently, the clinical drugs available for the treatment of cryptococcosis are limited to amphotericin B, azoles, and flucytosine.\n          <\/jats:p>","DOI":"10.1128\/spectrum.04562-22","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T14:22:37Z","timestamp":1678803757000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Antifungal Peptide SP1 Damages Polysaccharide Capsule of Cryptococcus neoformans and Enhances Phagocytosis of Macrophages"],"prefix":"10.1128","volume":"11","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China"},{"name":"Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China"},{"name":"School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China"},{"name":"Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilai","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China"},{"name":"Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Gastric Surgery, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8251-2306","authenticated-orcid":true,"given":"Yu V.","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China"},{"name":"Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","unstructured":"Denning D. Hidden crisis: how 150 people die every hour from fungal infection while the world turns a blind eye. https:\/\/www.gaffi.org\/wp-content\/uploads\/GAFFI-Final-Brochure-Aug-2017-pages.pdf. Accessed 10 August 2017."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00214"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2015.6"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760180111"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.859049"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00352-08"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2021.119978"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30243-8"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00511-0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/649858"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.46"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/10.Supplement_2.S436"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.3.1500-1504.2006"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00001-12"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep21489"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01186.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00483-19"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02183-16"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.9.3448-3453.1995"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.38.6.407.417"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.7.3988"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1002476"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.2.664-669.1998"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00619.x"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.8.2897-2903.1996"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.7.2846-2849.1996"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00636177"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.10.6350-6362.2005"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.3.1021-1033.2006"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00826-21"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.02194-21"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00742.x"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.145-153.2004"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.9.3360-3366.1995"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(80)90096-6"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(84)85172-1"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.5.2868-2875.2003"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00662-17"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.MB-0006-2014"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2164(09)01204-0"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12067"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.51.1.218-223.1986"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.3.2.287-294.1971"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.14.7.4912-4919.1994"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.5.2230-2236.1998"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.18.5636-5643.1999"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.6.1977-1983.1996"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.7.1.99"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201600538"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00995-06"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/528521"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.141"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2018.1431087"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2016198118"},{"key":"e_1_3_3_58_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts, approved standard","author":"Clinical and Laboratory Standards Institute","year":"2017","unstructured":"Clinical and Laboratory Standards Institute. 2017. Reference method for broth dilution antifungal susceptibility testing of yeasts, approved standard, 4th ed. CLSI document M27- A4. CLSI, Wayne, PA.","edition":"4"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00731-18"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.6.1437"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(00)80686-2"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.1.59-64.1991"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.01.023"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307223200"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07686.x"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02401.x"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2019.103258"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2015.06.001"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-019-01789-8"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002078"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00158-11"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02135-18"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.04562-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.04562-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T13:50:24Z","timestamp":1681393824000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.04562-22"}},"subtitle":[],"editor":[{"given":"Renato","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,4,13]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4,13]]}},"alternative-id":["10.1128\/spectrum.04562-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.04562-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,13]]},"assertion":[{"value":"2022-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e04562-22"}}