{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:24:48Z","timestamp":1770963888749,"version":"3.50.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1978,1,1]],"date-time":"1978-01-01T00:00:00Z","timestamp":252460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:p>\n            The effectiveness of cefazolin in\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            endocarditis has been questioned because of in vitro inactivation by staphylococcal beta-lactamase. Cefazolin, although inactivated in vitro by\n            <jats:italic>S. aureus<\/jats:italic>\n            beta-lactamase, was as effective as cephalothin in the treatment of left-sided\n            <jats:italic>S. aureus<\/jats:italic>\n            endocarditis in rabbits. Cefazolin (20 mg\/kg every 6 or 8 h), cephalothin (40 mg\/kg every 6 h), and methicillin (40 mg\/kg every 6 h), administered intramuscularly, were compared in the treatment of left-sided endocarditis caused in rabbits by a highly penicillin-resistant strain of\n            <jats:italic>S. aureus<\/jats:italic>\n            . The three antibiotics were all effective in reducing titers in vegetations. However, at the dose used, methicillin reduced the titers more rapidly than cephalothin or cefazolin. Cefazolin concentrations in serum were about double those achieved with cephalothin or methicillin. However, cefazolin was only half as active as methicillin and one-eighth as active as cephalothin in vitro in a serum assay. The half life in serum of cefazolin, cephalothin, and methicillin were each about 30 min. Serum bactericidal activities of the three antibiotics were very similar.\n          <\/jats:p>","DOI":"10.1128\/aac.13.1.74","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"74-77","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Treatment of Experimental\n            <i>Staphylococcus aureus<\/i>\n            Endocarditis: Comparison of Cephalothin, Cefazolin, and Methicillin"],"prefix":"10.1128","volume":"13","author":[{"given":"Jaime","family":"Carrizosa","sequence":"first","affiliation":[{"name":"Department of Medicine, The Medical College of Pennsylvania, Philadelphia, Pennsylvania 19129"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Medical College of Pennsylvania, Philadelphia, Pennsylvania 19129"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Kaye","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Medical College of Pennsylvania, Philadelphia, Pennsylvania 19129"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.13.1.74","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.13.1.74","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:15:19Z","timestamp":1645485319000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.13.1.74"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,1]]}},"alternative-id":["10.1128\/AAC.13.1.74"],"URL":"https:\/\/doi.org\/10.1128\/aac.13.1.74","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,1]]},"assertion":[{"value":"1978-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}