{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:24:08Z","timestamp":1767165848193,"version":"build-2238731810"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1973,7,1]],"date-time":"1973-07-01T00:00:00Z","timestamp":110332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1973,7]]},"abstract":"<jats:p>Clinical pharmacological studies of ticarcillin (\u03b1-carboxyl-3-thienylmethyl penicillin, BRL-2288) were conducted in patients with metastatic cancer and leukemia.After administration of 0.5 g intramuscularly, 1 g intramuscularly, and 1 g intravenously, the mean peak concentrations in serum were 18, 35, and 106 \u03bcg\/ml, respectively. Greater than 80% of ticarcillin was excreted in the urine during the subsequent 6-h period. The mean concentrations in the serum of patients 15 min after they received an intravenous injection of 4 g of ticarcillin with and without probenecid were 508 and 519 \u03bcg\/ml, respectively. Serum levels were determined in patients who received ticarcillin for therapy of infection in doses of 5 g every 6 h. The mean drug concentration in serum 15 min after the rapid administration of the first dose was 433 \u03bcg\/ml. Subsequent doses were given during a 2-h infusion and the study was repeated 2 days later. The average initial serum level (4 h after the completion of the preceding dose) was 19 \u03bcg\/ml, and the mean serum level at 15 min was 213 \u03bcg\/ml. Drug concentrations in the serum of patients receiving ticarcillin by infusion in doses of 3.5 g every 4 h were also determined. In patients with normal renal function, the average initial serum level (2 h after completion of the preceding dose) was 49 \u03bcg\/ml and the mean level at 15 min was 210 \u03bcg\/ml. Drug concentrations in the serum of patients with impaired renal function were considerably higher. No detectable levels of ticarcillin were found in the cerebrospinal fluid.<\/jats:p>","DOI":"10.1128\/aac.4.1.31","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T19:57:02Z","timestamp":1340827022000},"page":"31-36","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Clinical Pharmacology of Ticarcillin (\u03b1-Carboxyl-3-Thienylmethyl Penicillin, BRL-2288)"],"prefix":"10.1128","volume":"4","author":[{"given":"Victorio","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Department of Developmental Therapeutics, The University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas 77025"}]},{"given":"Jiro","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Department of Developmental Therapeutics, The University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas 77025"}]},{"given":"Gerald P.","family":"Bodey","sequence":"additional","affiliation":[{"name":"Department of Developmental Therapeutics, The University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas 77025"}]}],"member":"235","updated-by":[{"DOI":"10.1128\/aac.4.4.500","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[1973,10,1]],"date-time":"1973-10-01T00:00:00Z","timestamp":118281600000}}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.4.1.31","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.4.1.31","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T08:44:31Z","timestamp":1645433071000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.4.1.31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1973,7]]}},"alternative-id":["10.1128\/AAC.4.1.31"],"URL":"https:\/\/doi.org\/10.1128\/aac.4.1.31","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,7]]},"assertion":[{"value":"1973-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}