{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:46:23Z","timestamp":1761540383878},"reference-count":3,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>The lipopeptide antimicrobial daptomycin was administered intravenously at a dose of 4 mg\/kg of body weight to seven healthy male volunteers. The concentrations of daptomycin in plasma, cantharidin-induced inflammatory fluid, and urine were measured by a microbiological assay. The mean \u00b1 standard deviation peak concentrations in plasma and inflammatory fluid were 77.5 \u00b1 8.3 and 27.6 \u00b1 9.5 \u03bcg\/ml, respectively; the mean terminal elimination half-lives were 7.74 and 13.2 h, respectively. The overall penetration of total drug into the inflammatory fluid (measured by ratio of the area under the concentration-time curve from 0 to 24 h for inflammatory fluid compared with that for plasma) was 68.4%. The mean urinary recovery over 24 h was 59.7%.<\/jats:p>","DOI":"10.1128\/aac.46.1.31-33.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"31-33","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":78,"title":["Pharmacokinetics and Inflammatory Fluid Penetration of Intravenous Daptomycin in Volunteers"],"prefix":"10.1128","volume":"46","author":[{"given":"R.","family":"Wise","sequence":"first","affiliation":[{"name":"Department of Microbiology, City Hospital NHS Trust, Birmingham, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Gee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, City Hospital NHS Trust, Birmingham, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Microbiology, City Hospital NHS Trust, Birmingham, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Dvorchik","sequence":"additional","affiliation":[{"name":"Cubist Pharmaceuticals, Cambridge, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Microbiology, City Hospital NHS Trust, Birmingham, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.4.1062-1066.2000"},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/infdis\/142.1.77","volume":"142","year":"1980","unstructured":"Wise, R., A. P. Gillett, B. Cadge, R. Durham, and S. Baker. 1980. The influence of protein binding upon tissue fluid levels of six \u03b2 lactam antibiotics. J. Infect. Dis.142:77\u201382.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.2.318"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.46.1.31-33.2002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.46.1.31-33.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T17:30:16Z","timestamp":1645464616000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.46.1.31-33.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":3,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1128\/AAC.46.1.31-33.2002"],"URL":"https:\/\/doi.org\/10.1128\/aac.46.1.31-33.2002","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"2001-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}