{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:49:14Z","timestamp":1723337354547},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1976,2,1]],"date-time":"1976-02-01T00:00:00Z","timestamp":191980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1976,2]]},"abstract":"<jats:p>\n            Studies with\n            <jats:sup>14<\/jats:sup>\n            C-labeled isoleucine stereisomers have established that\n            <jats:sc>l<\/jats:sc>\n            -alloisoleucine,\n            <jats:sc>d<\/jats:sc>\n            -alloisoleucine, and\n            <jats:sc>d<\/jats:sc>\n            -isoleucine may function as precursors for the biogenesis of\n            <jats:sc>d<\/jats:sc>\n            -isoleucine and\n            <jats:italic>N<\/jats:italic>\n            -methyl-\n            <jats:sc>l<\/jats:sc>\n            -alloisoleucine residues in actinomycin.\n            <jats:sc>l<\/jats:sc>\n            -[\n            <jats:sup>14<\/jats:sup>\n            C]isoleucine appears to be employed chiefly for\n            <jats:sc>d<\/jats:sc>\n            -alloisoleucine (and\n            <jats:italic>N<\/jats:italic>\n            -methylisoleucine [?] formation); however, its role in the biosynthesis of\n            <jats:sc>d<\/jats:sc>\n            -isoleucine and\n            <jats:italic>N<\/jats:italic>\n            -methylalloisoleucine remains unclear. The potential pathway of biosynthesis of\n            <jats:sc>d<\/jats:sc>\n            -isoleucine and\n            <jats:italic>N<\/jats:italic>\n            -methyl-\n            <jats:sc>l<\/jats:sc>\n            -isoleucine is discussed.\n          <\/jats:p>","DOI":"10.1128\/aac.9.2.224","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"224-232","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Biogenetic Origin of the\n            <scp>d<\/scp>\n            -Isoleucine and\n            <i>N<\/i>\n            -Methyl-\n            <scp>l<\/scp>\n            -Alloisoleucine Residues in the Actinomycins"],"prefix":"10.1128","volume":"9","author":[{"given":"Takehiko","family":"Yajima","sequence":"first","affiliation":[{"name":"Department of Microbiology, Georgetown University, Schools of Medicine and Dentistry, Washington, D.C. 20007"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaarin","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Georgetown University, Schools of Medicine and Dentistry, Washington, D.C. 20007"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Georgetown University, Schools of Medicine and Dentistry, Washington, D.C. 20007"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.9.2.224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.9.2.224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T13:22:00Z","timestamp":1645449720000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.9.2.224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1976,2]]}},"alternative-id":["10.1128\/AAC.9.2.224"],"URL":"https:\/\/doi.org\/10.1128\/aac.9.2.224","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,2]]},"assertion":[{"value":"1976-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}