{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:18:55Z","timestamp":1762161535072},"reference-count":0,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1972,10,1]],"date-time":"1972-10-01T00:00:00Z","timestamp":86745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[1972,10]]},"abstract":"<jats:p>Plaque formation by A59 virus, a murine coronavirus, was facilitated in AL\/N and Balb mouse cells transformed by polyoma virus, simian virus 40, murine sarcoma virus, or mammary tumor virus. In these virus-transformed cells, A59 virus plaques were larger, they appeared earlier, and plaquing efficiencies were higher than in normal, untransformed cells. \u201cSpontaneously\u201d transformed AL\/N cells behaved similarly to untransformed cells, whereas \u201cspontaneously\u201d transformed Balb cells resembled virus-transformed cell hosts. Both untransformed and transformed AL\/N and Balb cells were permissive hosts for A59 virus. However, multiplication of A59 virus was enhanced at least fivefold in the virus-transformed AL\/N cell hosts. Larger differences (100-fold or greater) in A59 virus production were obtained during the first cycle of infection in Balb cells at low multiplicities and in AL\/N cells after multiple cycles of virus growth. In virus-transformed and \u201cspontaneously\u201d transformed Balb cells, A59 virus induced extensive syncytia formation.<\/jats:p>","DOI":"10.1128\/iai.6.4.501-507.1972","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T14:16:38Z","timestamp":1578060998000},"page":"501-507","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":120,"title":["Enhanced Growth of a Murine Coronavirus in Transformed Mouse Cells"],"prefix":"10.1128","volume":"6","author":[{"given":"Lawrence S.","family":"Sturman","sequence":"first","affiliation":[{"name":"Virus Laboratory, Division of Laboratories and Research, New York State Department of Health, Albany, New York 12201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth K.","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.6.4.501-507.1972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.6.4.501-507.1972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T13:13:36Z","timestamp":1646486016000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/iai.6.4.501-507.1972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1972,10]]}},"alternative-id":["10.1128\/iai.6.4.501-507.1972"],"URL":"https:\/\/doi.org\/10.1128\/iai.6.4.501-507.1972","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,10]]},"assertion":[{"value":"1972-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}