{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:22:36Z","timestamp":1770488556873,"version":"3.49.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The plethora of newly discovered vaccines implies that, in the future, many vaccines will have to be administered simultaneously to infants. We examined the potential interference with the immune response of several coadministered vaccines containing the same protein component, namely, tetanus toxoid (TT). Infants simultaneously receiving a tetravalent pneumococcal vaccine conjugated to TT (PncT) and a diphtheria-tetanus-pertussis\u2013poliovirus\u2013<jats:italic>Haemophilus influenzae<\/jats:italic>type b-tetanus conjugate vaccine showed significantly lower anti-<jats:italic>H. influenzae<\/jats:italic>type b polysaccharide (polyribosylribitol phosphate [PRP]) antibody concentrations than those receiving either a tetravalent pneumococcal vaccine conjugated to diphtheria toxoid or placebo. A dose range study showed that anti-PRP antibody concentrations were inversely related to the TT content of the PncT vaccines administered in infancy. Postimmunization antitetanus antibody concentrations were also affected adversely as the TT content of the coadministered vaccines was increased. This phenomenon, which we believe derives from interference by a common protein carrier, should be taken into account when the introduction of an immunization program including multiple conjugate vaccines is considered.<\/jats:p>","DOI":"10.1128\/iai.66.5.2093-2098.1998","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T15:25:27Z","timestamp":1577805927000},"page":"2093-2098","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":196,"title":["Reduced Response to Multiple Vaccines Sharing Common Protein Epitopes That Are Administered Simultaneously to Infants"],"prefix":"10.1128","volume":"66","author":[{"given":"Ron","family":"Dagan","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Pediatric Infectious Disease Unit, Soroka University Medical Center,1 and"},{"name":"<!--label omitted: 2-->Faculty of Health Sciences, Ben-Gurion University of the Negev,2 Beer-Sheva, Israel;"}]},{"given":"Juhani","family":"Eskola","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->National Public Health Institute, Helsinki, Finland3; and"}]},{"given":"Claude","family":"Leclerc","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Department of Immunology, Institut Pasteur, Paris,4 and"}]},{"given":"Odile","family":"Leroy","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->Pasteur Me\u0301rieux Connaught, Marnes la Coquette,5 France"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Ahman H. H. K\u00e4yhty H. Lehtonen O. Leroy J. Froeschle and J. Eskola. Streptococcus pneumoniae capsular polysaccharide-diphtheria toxoid conjugate vaccine is immunogenic in early infancy and able to induce immunologic memory. Pediatr. Infect. Dis. J. in press."},{"key":"e_1_3_2_3_2","unstructured":"Ahman H. K\u00e4yhty H. Leroy O. Froeschle J. Eskola J. Immunogenicity of tetravalent pneumococcal (Pnc) conjugate vaccines (PncD PncT) in Finnish infants abstr. 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Cho Y. H. Fuller S. Naso R. Overload of homologous carrier protein at the site of injection might cause a reduced immunogenicity of capsular polysaccharide conjugate vaccines abstr. G93 Program and Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. 1996 160 American Society for Microbiology Washington D.C"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"Granoff D. M. M. H. Rathore S. J. Holmes and P. D. Granoff. 1993. Effect of immunity to the carrier protein on antibody responses to Haemophilus influenzae type b conjugate vaccines. 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