{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:23:44Z","timestamp":1752229424943},"reference-count":14,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1978,12,1]],"date-time":"1978-12-01T00:00:00Z","timestamp":281318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1978,12]]},"abstract":"<jats:p>The replication in Bacillus subtilis of the staphylococcal R plasmids pE194, pBD15, pUB110, pSA0501, and pSA2100 has been studied in the presence of hydroxyurea. In all cases, an enrichment for covalently closed circular DNA compared with chromosomal DNA was observed. In this respect, hydroxyurea mimics the effect previously observed with pUB110, using strains carrying the conditional mutation dnaA13. This mutation has been reported to affect ribonucleotide reductase (G. W. Bazill and D. Karamata, Mol. Gen. Genet. 117:19-29, 1972). An explanation for these effects is offered, together with some supporting evidence.<\/jats:p>","DOI":"10.1128\/jb.136.3.1205-1207.1978","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T16:28:04Z","timestamp":1578068884000},"page":"1205-1207","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Differential effect of hydroxyurea on the replication of plasmid and chromosomal DNA in Bacillus subtilis"],"prefix":"10.1128","volume":"136","author":[{"given":"A G","family":"Shivakumar","sequence":"first","affiliation":[]},{"given":"D","family":"Dubnau","sequence":"additional","affiliation":[]}],"member":"235","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF00268833","article-title":"Temperaturesensitive mutants of B. subtilis defective in deoxyribonucleotide synthesis","volume":"117","author":"Bazill G. W.","year":"1972","unstructured":"Bazill , G. W. , and D. Karamata . 1972 . Temperaturesensitive mutants of B. subtilis defective in deoxyribonucleotide synthesis . Mol. Gen. Genet. 117 : 19 - 29 .","journal-title":"Mol. Gen. Genet."},{"key":"p_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/newbio237072a0","article-title":"Inhibition of bacterial DNA replication by 6-(phydroxyphenylazo)-uracil","volume":"237","author":"Brown N. C.","year":"1972","unstructured":"Brown , N. C. , C. L. Wisseman HI , and T. Matsushita . 1972 . Inhibition of bacterial DNA replication by 6-(phydroxyphenylazo)-uracil . Nature (London) New Biol. 237 : 72 - 74 .","journal-title":"Nature (London) New Biol."},{"key":"p_3","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1073\/pnas.74.4.1680","article-title":"Replication and expression of plasmids from Staphylococcus aureus in Bacillus subtilis","volume":"74","author":"Ehrlich S. D.","year":"1977","unstructured":"Ehrlich , S. D. 1977 . Replication and expression of plasmids from Staphylococcus aureus in Bacillus subtilis . Proc. Natl. Acad. Sci. U.S.A. 74 : 1680 - 1682 .","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"p_4","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1073\/pnas.75.3.1433","article-title":"DNA cloning in Bacillus subtilis","volume":"75","author":"Ehrlich S. D.","year":"1978","unstructured":"Ehrlich , S. D. 1978 . DNA cloning in Bacillus subtilis . Proc. Natl. Acad. Sci. U.S.A. 75 : 1433 - 1436 .","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"p_5","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1128\/jb.134.1.318-329.1978","article-title":"Characterization of Staphylococcus aureus plasmids introduced by transformation into Bacillus subtilis","volume":"134","author":"Gryczan T. J.","year":"1978","unstructured":"Gryczan , T. J. , S. Contente , and D. Dubnau . 1978 . Characterization of Staphylococcus aureus plasmids introduced by transformation into Bacillus subtilis . J. Bacteriol. 134 : 318 - 329 .","journal-title":"J. Bacteriol."},{"key":"p_6","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1073\/pnas.75.3.1428","article-title":"Construction and properties of chimeric plasmids in Bacillus subtilis","volume":"75","author":"Gryczan T. J.","year":"1978","unstructured":"Gryczan , T. J. , and D. Dubnau . 1978 . Construction and properties of chimeric plasmids in Bacillus subtilis . Proc. Natl. Acad. Sci. U.S.A. 75 : 1428 - 1432 .","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"p_7","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1128\/jb.124.2.597-601.1975","article-title":"Recombinant plasmid obtained from two different, compatible staphylococcal plasmids","volume":"124","author":"Iordanescu S.","year":"1975","unstructured":"Iordanescu , S. 1975 . Recombinant plasmid obtained from two different, compatible staphylococcal plasmids . J. Bacteriol. 124 : 597 - 601 .","journal-title":"J. Bacteriol."},{"key":"p_8","first-page":"111","article-title":"Three distinct plasmids originatin g in the same Staphylococcus aureus strain","volume":"35","author":"Iordinescu S.","year":"1976","unstructured":"Iordinescu , S. 1976 . Three distinct plasmids originatin g in the same Staphylococcus aureus strain . Arch. Roum. Pathol. Exp. Microbiol. 35 : 111 - 118 .","journal-title":"Arch. Roum. Pathol. Exp. Microbiol."},{"key":"p_9","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1073\/pnas.75.3.1423","article-title":"Molecular cloning of genetically active fragments of Bacillus DNA in Bacillus subtilis and properties of the vector plasmid pUB110","volume":"75","author":"Keggins K. M.","year":"1978","unstructured":"Keggins , K. M. , P. S. Lovett , and E. J. Duvall . 1978 . 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Chromosome replication in toluenized Bacillus subtilis cells . Nature (London) New Biol. 232 : 111 - 114 .","journal-title":"Nature (London) New Biol."},{"key":"p_12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0147-619X(78)90055-0","article-title":"Plasmid replication in dna Ts mutants of Bacillus subtilis","volume":"1","author":"Shivakumar A. G.","year":"1978","unstructured":"Shivakumar , A. G. , and D. Dubnau . 1978 . Plasmid replication in dna Ts mutants of Bacillus subtilis . Plasmid 1 : 405 - 416 .","journal-title":"Plasmid"},{"key":"p_13","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1128\/jb.112.3.1321-1334.1972","article-title":"Mechanism of inhibition of deoxyribonucleic acid synthesis in Escherichia coli by hydroxyurea","volume":"112","author":"Sinha N. K.","year":"1972","unstructured":"Sinha , N. K. , and D. P. Snustad . 1972 . Mechanism of inhibition of deoxyribonucleic acid synthesis in Escherichia coli by hydroxyurea . J. 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