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Metcalf, and B. L. Wanner, J. Bacteriol. 174:2501-2510, 1992). In contrast, here it is shown that Salmonella typhimurium LT2 carries genes only for the phosphonatase pathway. Genes for the S. typhimurium phosphonatase pathway were cloned by complementation of E. coli delta phn mutants. Genes for these pathways were proven not to be homologous and to lie in different chromosomal regions. The S. typhimurium phn locus lies near 10 min; the E. coli phn locus lies near 93 min. The S. typhimurium phn gene cluster is about 7.2 kb in length and, on the basis of gene fusion analysis, appears to consist of two (or more) genes or operons that are divergently transcribed. Like that of the E. coli phn locus, the expression of the S. typhimurium phn locus is activated under conditions of Pi limitation and is subject to Pho regulon control. This was shown both by complementation of the appropriate E. coli mutants and by the construction of S. typhimurium mutants with lesions in the phoB and pst loci, which are required for activation and inhibition of Pho regulon gene expression, respectively. Complementation studies indicate that the S. typhimurium phn locus probably includes genes both for phosphonate transport and for catalysis of C-P bond cleavage.<\/jats:p>","DOI":"10.1128\/jb.177.22.6411-6421.1995","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T15:42:21Z","timestamp":1478706141000},"page":"6411-6421","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":96,"title":["Molecular cloning, mapping, and regulation of Pho regulon genes for phosphonate breakdown by the phosphonatase pathway of Salmonella typhimurium LT2"],"prefix":"10.1128","volume":"177","author":[{"given":"W","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W W","family":"Metcalf","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K S","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B L","family":"Wanner","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","unstructured":"Agrawal D. 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