{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T11:56:45Z","timestamp":1780315005428,"version":"3.54.1"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The in vitro antifungal activities of SCH56592, MK-0991, and LY303366 against 83 isolates of\n            <jats:italic>Acremonium strictum<\/jats:italic>\n            ,\n            <jats:italic>Aspergillus flavus<\/jats:italic>\n            ,\n            <jats:italic>Aspergillus fumigatus<\/jats:italic>\n            ,\n            <jats:italic>Aspergillus terreus<\/jats:italic>\n            ,\n            <jats:italic>Bipolaris<\/jats:italic>\n            spp.,\n            <jats:italic>Blastomyces dermatitidis<\/jats:italic>\n            ,\n            <jats:italic>Cladophialophora bantiana<\/jats:italic>\n            ,\n            <jats:italic>Fusarium oxysporum<\/jats:italic>\n            ,\n            <jats:italic>Fusarium solani<\/jats:italic>\n            ,\n            <jats:italic>Histoplasma capsulatum<\/jats:italic>\n            ,\n            <jats:italic>Phialophora<\/jats:italic>\n            spp.,\n            <jats:italic>Pseudallescheria boydii<\/jats:italic>\n            ,\n            <jats:italic>Rhizopus arrhizus<\/jats:italic>\n            ,\n            <jats:italic>Scedosporium prolificans<\/jats:italic>\n            , and\n            <jats:italic>Sporothrix schenckii<\/jats:italic>\n            were compared. The in vitro activities of these agents against 104 isolates of yeast pathogens of\n            <jats:italic>Candida<\/jats:italic>\n            spp.,\n            <jats:italic>Cryptococcus neoformans<\/jats:italic>\n            , and\n            <jats:italic>Trichosporon beigelii<\/jats:italic>\n            were also compared. MICs were determined by following a procedure under evaluation by the National Committee for Clinical Laboratory Standards (NCCLS) for broth microdilution testing of the filamentous fungi (visual MICs) and the NCCLS M27-A broth microdilution method for yeasts (both visual and turbidimetric MICs). The in vitro fungicidal activity of SCH56592 was superior (minimum fungicidal concentrations [MFCs], 0.25 to 4 \u03bcg\/ml for 7 of 18 species tested) to those of MK-0991 and LY303366 (MFCs, 8 to &gt;16 \u03bcg\/ml for all species tested) for the molds tested, but the echinocandins had a broader spectrum of fungicidal activity (MFCs at which 90% of strains are inhibited [MFC\n            <jats:sub>90<\/jats:sub>\n            s], 0.5 to 4 \u03bcg\/ml for 6 of 9 species tested) than SCH56592 (MFC\n            <jats:sub>90<\/jats:sub>\n            s, 0.25 to 8 \u03bcg\/ml for 4 of 9 species tested) against most of the yeasts tested. Neither echinocandin had in vitro activity (MICs, &gt;16 \u03bcg\/ml) against\n            <jats:italic>C. neoformans<\/jats:italic>\n            and\n            <jats:italic>T. beigelii<\/jats:italic>\n            , while the SCH56592 MICs ranged from 0.12 to 1.0 \u03bcg\/ml for these two species. The MICs of the three agents for the other species ranged from &lt;0.03 to 4 \u03bcg\/ml. These results suggest that these new agents have broad-spectrum activities in vitro; their effectiveness in the treatment of human mycoses is to be determined.\n          <\/jats:p>","DOI":"10.1128\/jcm.36.10.2950-2956.1998","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T17:23:41Z","timestamp":1577813021000},"page":"2950-2956","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":460,"title":["Comparison of In Vitro Activities of the New Triazole SCH56592 and the Echinocandins MK-0991 (L-743,872) and LY303366 against Opportunistic Filamentous and Dimorphic Fungi and Yeasts"],"prefix":"10.1128","volume":"36","author":[{"given":"Ana","family":"Espinel-Ingroff","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0049"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.Supplement_1.S43"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.11.2326"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.8.1835"},{"key":"e_1_3_2_5_2","first-page":"226","article-title":"Fungal infections: a growing threat","volume":"111","author":"Dixon D. 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Antifungal agents in the 1990s: current status and future developments.Drugs631997639649","journal-title":"Drugs"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.Supplement_1.S41"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.9.1957"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.7.1480"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.10.2310"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.7.1558"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/am.28.2.218-222.1974"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199303000-00002"},{"key":"e_1_3_2_23_2","unstructured":"National Committee for Clinical Laboratory Standards\nReference method for broth dilution antifungal susceptibility testing of yeasts M27-A.\n1997\nNational Committee for Clinical Laboratory Standards\nWayne Pa"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(95)00010-0"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.5.1124"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.7.1504"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.1990.33.6.296"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.8.1910"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.4.763"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.1.129"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.5.1156"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.7.1612"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.4.900"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.4.863"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.36.10.2950-2956.1998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.36.10.2950-2956.1998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T23:33:21Z","timestamp":1646436801000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.36.10.2950-2956.1998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["10.1128\/JCM.36.10.2950-2956.1998"],"URL":"https:\/\/doi.org\/10.1128\/jcm.36.10.2950-2956.1998","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]},"assertion":[{"value":"1998-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}