{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:41:26Z","timestamp":1761129686106},"reference-count":22,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Helicobacter pylori<\/jats:italic>\n            infection can be detected by several invasive tests based on gastroscopy and by noninvasive methods such as serologic assays. Noninvasive tests can be used not only in addition to invasive tests but also by themselves to screen for\n            <jats:italic>H. pylori<\/jats:italic>\n            infection in patients who are not in urgent need of endoscopy. Lately, rapid qualitative serologic tests have been developed. In the present study, the accuracy of a novel rapid whole-blood test, Pyloriset Screen, detecting immunoglobulin G (IgG) and IgA antibodies against\n            <jats:italic>H. pylori<\/jats:italic>\n            was evaluated. A total of 207 consecutive adult outpatients referred for upper endoscopy were enrolled. Gastric biopsy specimens were taken from the antrum and corpus for histologic examination and rapid urease testing. Cultures were available for 113 patients. Serum samples collected from all patients were tested for\n            <jats:italic>H. pylori<\/jats:italic>\n            antibodies by two enzyme immunoassays (EIAs) (Pyloriset EIA and an in-house EIA), a rapid latex agglutination test (Pyloriset Dry), and Pyloriset Screen. Patients were considered\n            <jats:italic>H. pylori<\/jats:italic>\n            positive if helicobacters were seen on histologic examination (77 patients) or, if in combination with histologically verified (although helicobacter-negative) gastritis, their IgG antibody titers were elevated in the two EIAs (five patients). The Pyloriset Screen test had a sensitivity of 95%, a specificity of 94%, a positive predictive value of 91%, and a negative predictive value of 97%. Among 63 patients under the age of 45 years, the Pyloriset Screen test did not miss a single\n            <jats:italic>H. pylori<\/jats:italic>\n            diagnosis, and only 1 patient had a false-positive result. Pyloriset Screen could be used reliably to screen for\n            <jats:italic>H. pylori<\/jats:italic>\n            infection.\n          <\/jats:p>","DOI":"10.1128\/jcm.36.4.955-957.1998","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T17:29:20Z","timestamp":1577813360000},"page":"955-957","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Evaluation of Pyloriset Screen, a Rapid Whole-Blood Diagnostic Test for\n            <i>Helicobacter pylori<\/i>\n            Infection"],"prefix":"10.1128","volume":"36","author":[{"given":"Aino","family":"Oksanen","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Herttoniemi Municipal Hospital, FIN-00800 Helsinki,1"}]},{"given":"Lea","family":"Veijola","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Herttoniemi Municipal Hospital, FIN-00800 Helsinki,1"}]},{"given":"Pentti","family":"Sipponen","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Pathology, Jorvi Hospital, FIN-02740 Espoo,2 and"}]},{"given":"Knut-Olof","family":"Schauman","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Herttoniemi Municipal Hospital, FIN-00800 Helsinki,1"}]},{"given":"Hilpi","family":"Rautelin","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Department of Bacteriology and Immunology, The Haartman Institute, FIN-00014 University of Helsinki,3 Finland"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.1.184-186.1997"},{"key":"e_1_3_2_3_2","first-page":"188","article-title":"Patients, payers, and paradigm shifts: what to do about Helicobacter pylori","volume":"91","author":"Graham D. Y.","year":"1996","unstructured":"Graham D. Y. Rabeneck L. Patients, payers, and paradigm shifts: what to do about Helicobacter pylori.Am. J. Gastroenterol. 91 1996 188 189","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_3_2_4_2","first-page":"177","article-title":"Schistosomes, liver flukes and Helicobacter pylori","volume":"61","author":"International Agency for Research on Cancer","year":"1994","unstructured":"International Agency for Research on Cancer Schistosomes, liver flukes and Helicobacter pylori.IARC Monogr. Eval. Carcinog. Risks Hum. 61 1994 177 220","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"e_1_3_2_5_2","first-page":"1865","article-title":"Minimum analysis requirement for the detection of Helicobacter pylori infection by the 13C-urea breath test","volume":"88","author":"Klein P. D.","year":"1993","unstructured":"Klein P. D. Graham D. Y. Minimum analysis requirement for the detection of Helicobacter pylori infection by the 13C-urea breath test.Am. J. Gastroenterol. 88 1993 1865 1869","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90929-W"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199701000-00002"},{"key":"e_1_3_2_8_2","first-page":"S116","article-title":"Helicobacter pylori","volume":"89","author":"Marshall B. J.","year":"1994","unstructured":"Marshall B. J. Helicobacter pylori.Am. J. Gastroenterol. 89 1994 S116 S128","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1985.tb113443.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.1.292-294.1997"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.10.969"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520010077036"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(21)00265-X"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92340-3"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1991.tb01468.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91301-P"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.4.454"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529209000173"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.4.319"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90085-4"},{"key":"e_1_3_2_21_2","first-page":"147","article-title":"The diagnostic value of enzyme immunoassay and immunoblot in monitoring eradication of Helicobacter pylori","volume":"32","author":"S\u00f6rberg M.","year":"1997","unstructured":"S\u00f6rberg M. Engstrand L. Str\u00f6m M. J\u00f6nsson K. \u00c5. J\u00f6rbeck H. Granstr\u00f6m M. The diagnostic value of enzyme immunoassay and immunoblot in monitoring eradication of Helicobacter pylori.Scand. J. Gastroenterol. 32 1997 147 151","journal-title":"Scand. J. Gastroenterol."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.70.829.809"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199407000-00003"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.36.4.955-957.1998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.36.4.955-957.1998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T23:42:30Z","timestamp":1646437350000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.36.4.955-957.1998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,4]]}},"alternative-id":["10.1128\/JCM.36.4.955-957.1998"],"URL":"https:\/\/doi.org\/10.1128\/jcm.36.4.955-957.1998","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4]]},"assertion":[{"value":"1997-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}