{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:09:42Z","timestamp":1761523782848},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1992,2,1]],"date-time":"1992-02-01T00:00:00Z","timestamp":696902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:p>A cDNA encoding NF-IL6, an interleukin-6 (IL-6)-regulated human nuclear factor of the C\/EBP family, is demonstrated to complement the transactivation function of E1A. The endogenous NF-IL6 level varies according to cell type and correlates positively with an IL-6-regulated cellular E1A-substituting activity that was described recently (J.M. Spergel and S. Chen-Kiang, Proc. Natl. Acad. Sci. USA 88:6472-6476, 1991). When expressed by transfection in cells which contain low levels of NF-IL6 and are incapable of complementing the function of E1A proteins, NF-IL6 also transactivates the E1A-responsive E2ae and E1B promoters, to the same magnitude as E1A. Activation by NF-IL6 is concentration dependent and sequence specific: mutational studies of the E2ae promoter suggest that the promoter-proximal NF-IL6 recognition site functions as a dominant negative regulatory site whereas the promoter-distal NF-IL6 recognition site is positively regulated at low NF-IL6 concentrations and negatively regulated when the NF-IL6 level is high. Consistent with these functions, NF-IL6 alone is sufficient to complement an E1A deletion mutant dl312 in viral infection, when expressed at appropriate concentrations. These results identify NF-IL6 as a sequence-specific cellular nuclear factor which regulates E1A-responsive genes in the absence of E1A.<\/jats:p>","DOI":"10.1128\/jvi.66.2.1021-1030.1992","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T16:18:44Z","timestamp":1578327524000},"page":"1021-1030","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":71,"title":["NF-IL6, a member of the C\/EBP family, regulates E1A-responsive promoters in the absence of E1A"],"prefix":"10.1128","volume":"66","author":[{"given":"J M","family":"Spergel","sequence":"first","affiliation":[{"name":"Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Hsu","sequence":"additional","affiliation":[{"name":"Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Akira","sequence":"additional","affiliation":[{"name":"Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Thimmappaya","sequence":"additional","affiliation":[{"name":"Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Chen-Kiang","sequence":"additional","affiliation":[{"name":"Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.66.2.1021-1030.1992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.66.2.1021-1030.1992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T00:52:05Z","timestamp":1646441525000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.66.2.1021-1030.1992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,2]]}},"alternative-id":["10.1128\/jvi.66.2.1021-1030.1992"],"URL":"https:\/\/doi.org\/10.1128\/jvi.66.2.1021-1030.1992","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,2]]},"assertion":[{"value":"1992-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}