{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:12:38Z","timestamp":1770725558112,"version":"3.49.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:p>Hepatitis C virus (HCV) is a major causative agent of parenterally transmitted non-A, non-B hepatitis. The genomic region encoding the virion-associated core protein is relatively conserved among HCV strains. To generate a DNA vaccine capable of expressing the HCV core protein, the genomic region encoding amino acid residues 1 to 191 of the HCV-1 strain was amplified and cloned into an eukaryotic expression vector. Intramuscular inoculation of recombinant plasmid DNA into BALB\/c mice (H-2d) generated core-specific antibody responses, lymphoproliferative responses, and cytotoxic T-lymphocyte activity. Our results suggest that the HCV core polynucleotide warrants further investigation as a potential vaccine against HCV infection.<\/jats:p>","DOI":"10.1128\/jvi.69.9.5859-5863.1995","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T21:37:14Z","timestamp":1578346634000},"page":"5859-5863","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":108,"title":["Immune responses to plasmid DNA encoding the hepatitis C virus core protein"],"prefix":"10.1128","volume":"69","author":[{"given":"L M","family":"Lagging","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Saint Louis University Health Sciences Center, MO 63104, USA."}]},{"given":"K","family":"Meyer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Saint Louis University Health Sciences Center, MO 63104, USA."}]},{"given":"D","family":"Hoft","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Saint Louis University Health Sciences Center, MO 63104, USA."}]},{"given":"M","family":"Houghton","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Saint Louis University Health Sciences Center, MO 63104, USA."}]},{"given":"R B","family":"Belshe","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Saint Louis University Health Sciences Center, MO 63104, USA."}]},{"given":"R","family":"Ray","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Saint Louis University Health Sciences Center, MO 63104, USA."}]}],"member":"235","container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.69.9.5859-5863.1995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.69.9.5859-5863.1995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T13:16:13Z","timestamp":1646486173000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.69.9.5859-5863.1995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["10.1128\/jvi.69.9.5859-5863.1995"],"URL":"https:\/\/doi.org\/10.1128\/jvi.69.9.5859-5863.1995","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]},"assertion":[{"value":"1995-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}