{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:52:51Z","timestamp":1770724371184,"version":"3.49.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:p>Lymphocytic choriomeningitis virus (LCMV) is known to induce strong, polyclonal cytotoxic T-lymphocyte (CTL) responses. Using a set of variant peptides derived from the major CTL epitope of LCMV, we analyzed the functional fine specificity of the LCMV-specific CTL response. During the primary response, almost all the tested peptides were recognized. In contrast, the secondary response was purged of all minor cross-reactivities and very few peptides were significantly recognized. This study is the first demonstration of the functional maturation of a T-cell response and has important clinical and biological implications.<\/jats:p>","DOI":"10.1128\/jvi.71.8.5764-5768.1997","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T22:10:12Z","timestamp":1578348612000},"page":"5764-5768","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Functional management of an antiviral cytotoxic T-cell response"],"prefix":"10.1128","volume":"71","author":[{"given":"M F","family":"Bachmann","sequence":"first","affiliation":[{"name":"Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada. bachmann@oci.utoronto.ca"}]},{"given":"D E","family":"Speiser","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada. bachmann@oci.utoronto.ca"}]},{"given":"P S","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada. bachmann@oci.utoronto.ca"}]}],"member":"235","container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.71.8.5764-5768.1997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.71.8.5764-5768.1997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T13:27:28Z","timestamp":1646486848000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.71.8.5764-5768.1997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["10.1128\/jvi.71.8.5764-5768.1997"],"URL":"https:\/\/doi.org\/10.1128\/jvi.71.8.5764-5768.1997","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8]]},"assertion":[{"value":"1997-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}